increased circulating alanine transaminase level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction (Mammalian Phenotype Ontology, MP_0002941)
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67 gene mutations causing the increased circulating alanine transaminase level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ACOX1 acyl-CoA oxidase 1, palmitoyl
ANK1 ankyrin 1, erythrocytic
ARNTL aryl hydrocarbon receptor nuclear translocator-like
BBS5 Bardet-Biedl syndrome 5
BCO1 beta-carotene oxygenase 1
BCR breakpoint cluster region
BHMT betaine--homocysteine S-methyltransferase
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1
C3 complement component 3
C5AR2 complement component 5a receptor 2
CCR2 chemokine (C-C motif) receptor 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLEC4G C-type lectin domain family 4, member G
CRH corticotropin releasing hormone
CTH cystathionine gamma-lyase
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DEGS1 delta(4)-desaturase, sphingolipid 1
DFNB31 deafness, autosomal recessive 31
DNM1L dynamin 1-like
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAIM Fas apoptotic inhibitory molecule
FFAR4 free fatty acid receptor 4
FKRP fukutin related protein
GCLM glutamate-cysteine ligase, modifier subunit
GLMP glycosylated lysosomal membrane protein
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNMT glycine N-methyltransferase
GSTA4 glutathione S-transferase alpha 4
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
IL22 interleukin 22
IL27RA interleukin 27 receptor, alpha
KPNA1 karyopherin alpha 1 (importin alpha 5)
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MC4R melanocortin 4 receptor
MIR122 microRNA 122
MPV17 MpV17 mitochondrial inner membrane protein
MST1R macrophage stimulating 1 receptor
MTA2 metastasis associated 1 family, member 2
NCOA5 nuclear receptor coactivator 5
NFE2L2 nuclear factor, erythroid 2-like 2
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
OMA1 OMA1 zinc metallopeptidase
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PHF20 PHD finger protein 20
PHYH phytanoyl-CoA 2-hydroxylase
PILRA paired immunoglobin-like type 2 receptor alpha
PROX1 prospero homeobox 1
RHBDD3 rhomboid domain containing 3
SIK3 SIK family kinase 3
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SLC38A10 solute carrier family 38, member 10
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SRXN1 sulfiredoxin 1
TGFB1 transforming growth factor, beta 1
TRAFD1 TRAF-type zinc finger domain containing 1
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UNC93B1 unc-93 homolog B1 (C. elegans)
ZDHHC13 zinc finger, DHHC-type containing 13