increased circulating free fatty acid level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description higher than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues (Mammalian Phenotype Ontology, MP_0001554)
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61 gene mutations causing the increased circulating free fatty acid level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACADL acyl-CoA dehydrogenase, long chain
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOQ adiponectin, C1Q and collagen domain containing
ANGPTL6 angiopoietin-like 6
ANKRD26 ankyrin repeat domain 26
APC adenomatous polyposis coli
BCO1 beta-carotene oxygenase 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C3 complement component 3
CCDC120 coiled-coil domain containing 120
CCDC80 coiled-coil domain containing 80
CD36 CD36 molecule (thrombospondin receptor)
CPT1A carnitine palmitoyltransferase 1A (liver)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CYB561 cytochrome b561
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FABP3 fatty acid binding protein 3, muscle and heart
FGF21 fibroblast growth factor 21
FOXA2 forkhead box A2
G0S2 G0/G1 switch 2
GCK glucokinase (hexokinase 4)
GNAS GNAS complex locus
HADH hydroxyacyl-CoA dehydrogenase
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HRH1 histamine receptor H1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
LDLR low density lipoprotein receptor
LEPR leptin receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPE lipase, hormone-sensitive
LONRF3 LON peptidase N-terminal domain and ring finger 3
MC4R melanocortin 4 receptor
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MTRF1L mitochondrial translational release factor 1-like
MYO7A myosin VIIA
NCOR1 nuclear receptor corepressor 1
NMU neuromedin U
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY1R neuropeptide Y receptor Y1
NRCAM neuronal cell adhesion molecule
OSMR oncostatin M receptor
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEX11A peroxisomal biogenesis factor 11 alpha
PLIN5 perilipin 5
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCI protein kinase C, iota
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2
PTRF polymerase I and transcript release factor
SGMS2 sphingomyelin synthase 2
TBC1D4 TBC1 domain family, member 4
THEM5 thioesterase superfamily member 5
TLR2 toll-like receptor 2
TXNIP thioredoxin interacting protein
TYK2 tyrosine kinase 2
ZEB1 zinc finger E-box binding homeobox 1