increased circulating glucagon level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the blood concentration of the peptide hormone secreted by the alpha cells of the pancreas that normally plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes (Mammalian Phenotype Ontology, MP_0002712)
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17 gene mutations causing the increased circulating glucagon level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BRD2 bromodomain containing 2
CRH corticotropin releasing hormone
DPP4 dipeptidyl-peptidase 4
FTO fat mass and obesity associated
G6PC3 glucose 6 phosphatase, catalytic, 3
GCGR glucagon receptor
KLF15 Kruppel-like factor 15
LEPR leptin receptor
MIR375 microRNA 375
NQO1 NAD(P)H dehydrogenase, quinone 1
PROX1 prospero homeobox 1
RIMS2 regulating synaptic membrane exocytosis 2
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SSTR5 somatostatin receptor 5
THRA thyroid hormone receptor, alpha
ZBTB20 zinc finger and BTB domain containing 20