increased circulating interleukin-1 beta level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane (Mammalian Phenotype Ontology, MP_0008641)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008641
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Genes

24 gene mutations causing the increased circulating interleukin-1 beta level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BRD2 bromodomain containing 2
C3AR1 complement component 3a receptor 1
CTSE cathepsin E
IL10 interleukin 10
IL10RA interleukin 10 receptor, alpha
IL1R1 interleukin 1 receptor, type I
IL27RA interleukin 27 receptor, alpha
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
MEFV Mediterranean fever
MEP1A meprin A, alpha (PABA peptide hydrolase)
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NLRP3 NLR family, pyrin domain containing 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PRF1 perforin 1 (pore forming protein)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB27A RAB27A, member RAS oncogene family
SOCS2 suppressor of cytokine signaling 2
STX11 syntaxin 11
TBK1 TANK-binding kinase 1
THBD thrombomodulin
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
Funding