increased circulating interleukin-4 level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells (Mammalian Phenotype Ontology, MP_0008602)
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9 gene mutations causing the increased circulating interleukin-4 level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
FOXP3 forkhead box P3
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HEXB hexosaminidase B (beta polypeptide)
IL27RA interleukin 27 receptor, alpha
IL4R interleukin 4 receptor
IRF1 interferon regulatory factor 1
MTA2 metastasis associated 1 family, member 2
NLRP3 NLR family, pyrin domain containing 3
PPIA peptidylprolyl isomerase A (cyclophilin A)