increased circulating leptin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance (Mammalian Phenotype Ontology, MP_0005669)
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89 gene mutations causing the increased circulating leptin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADIPOR1 adiponectin receptor 1
ADRA1B adrenoceptor alpha 1B
ALMS1 Alstrom syndrome protein 1
ALOX5 arachidonate 5-lipoxygenase
ANGPTL6 angiopoietin-like 6
ANKRD26 ankyrin repeat domain 26
APOC3 apolipoprotein C-III
ASIP agouti signaling protein
BBS1 Bardet-Biedl syndrome 1
BBS12 Bardet-Biedl syndrome 12
BBS4 Bardet-Biedl syndrome 4
BRD2 bromodomain containing 2
BRS3 bombesin-like receptor 3
CCDC80 coiled-coil domain containing 80
CCL13 chemokine (C-C motif) ligand 13
CD36 CD36 molecule (thrombospondin receptor)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLOCK clock circadian regulator
CPE carboxypeptidase E
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTF1 cardiotrophin 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DRD3 dopamine receptor D3
ESR1 estrogen receptor 1
FABP2 fatty acid binding protein 2, intestinal
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FTO fat mass and obesity associated
GHR growth hormone receptor
GNAS GNAS complex locus
GPR26 G protein-coupled receptor 26
GUCY2C guanylate cyclase 2C
HDC histidine decarboxylase
HRH1 histamine receptor H1
HRH3 histamine receptor H3
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IL1R1 interleukin 1 receptor, type I
IRS2 insulin receptor substrate 2
KDM3A lysine (K)-specific demethylase 3A
LEP leptin
LEPR leptin receptor
LIF leukemia inhibitory factor
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MKKS McKusick-Kaufman syndrome
MRAP2 melanocortin 2 receptor accessory protein 2
NCOA1 nuclear receptor coactivator 1
NCOA3 nuclear receptor coactivator 3
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NMU neuromedin U
NOS3 nitric oxide synthase 3 (endothelial cell)
NPBWR1 neuropeptides B/W receptor 1
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OMA1 OMA1 zinc metallopeptidase
OSMR oncostatin M receptor
PCSK1 proprotein convertase subtilisin/kexin type 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLIN1 perilipin 1
PLSCR3 phospholipid scramblase 3
PNPLA2 patatin-like phospholipase domain containing 2
POMC proopiomelanocortin
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PREP prolyl endopeptidase
PRKCI protein kinase C, iota
PRLH prolactin releasing hormone
PRLHR prolactin releasing hormone receptor
PROX1 prospero homeobox 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYY peptide YY
RAI1 retinoic acid induced 1
RSC1A1 regulatory solute carrier protein, family 1, member 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SELM selenoprotein M
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SIM1 single-minded family bHLH transcription factor 1
SQSTM1 sequestosome 1
SSTR5 somatostatin receptor 5
STEAP4 STEAP family member 4
THRA thyroid hormone receptor, alpha
UBB ubiquitin B
WDTC1 WD and tetratricopeptide repeats 1
ZEB1 zinc finger E-box binding homeobox 1