increased germinal center b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen (Mammalian Phenotype Ontology, MP_0008177)
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14 gene mutations causing the increased germinal center b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
IL2 interleukin 2
ITK IL2-inducible T-cell kinase
PKN1 protein kinase N1
POLB polymerase (DNA directed), beta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RGS13 regulator of G-protein signaling 13
S1PR2 sphingosine-1-phosphate receptor 2
TNIP1 TNFAIP3 interacting protein 1
TYROBP TYRO protein tyrosine kinase binding protein
WAS Wiskott-Aldrich syndrome