increased heart rate Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A rapid heartrate that exceeds the range of the normal resting heartrate for age. (Human Phenotype Ontology, HP_0001649)
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58 gene mutations causing the increased heart rate phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADCY10 adenylate cyclase 10 (soluble)
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADRA2A adrenoceptor alpha 2A
ARL6 ADP-ribosylation factor-like 6
ARRB1 arrestin, beta 1
ASPH aspartate beta-hydroxylase
BBS1 Bardet-Biedl syndrome 1
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CALCB calcitonin-related polypeptide beta
CASQ2 calsequestrin 2 (cardiac muscle)
CD47 CD47 molecule
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DRD2 dopamine receptor D2
EGFR epidermal growth factor receptor
FKBP1B FK506 binding protein 1B, 12.6 kDa
GJA1 gap junction protein, alpha 1, 43kDa
GJA5 gap junction protein, alpha 5, 40kDa
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HCRT hypocretin (orexin) neuropeptide precursor
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
IER3 immediate early response 3
JUP junction plakoglobin
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
LHX1 LIM homeobox 1
MCHR1 melanin-concentrating hormone receptor 1
MGP matrix Gla protein
MPV17 MpV17 mitochondrial inner membrane protein
MTA1 metastasis associated 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
PDC phosducin
PNPLA2 patatin-like phospholipase domain containing 2
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
REN renin
RGS5 regulator of G-protein signaling 5
RNLS renalase, FAD-dependent amine oxidase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RYR2 ryanodine receptor 2 (cardiac)
SCN5A sodium channel, voltage gated, type V alpha subunit
SFRP2 secreted frizzled-related protein 2
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SOX4 SRY (sex determining region Y)-box 4
SP4 Sp4 transcription factor
SPP1 secreted phosphoprotein 1
TBX5 T-box 5
THRA thyroid hormone receptor, alpha
THRB thyroid hormone receptor, beta
TPH1 tryptophan hydroxylase 1
UBE3B ubiquitin protein ligase E3B
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor