increased immature b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity (Mammalian Phenotype Ontology, MP_0008214)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008214
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Genes

36 gene mutations causing the increased immature b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AKAP13 A kinase (PRKA) anchor protein 13
AR androgen receptor
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BMF Bcl2 modifying factor
BTK Bruton agammaglobulinemia tyrosine kinase
CD36 CD36 molecule (thrombospondin receptor)
CD69 CD69 molecule
CD72 CD72 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DLK1 delta-like 1 homolog (Drosophila)
EPS15 epidermal growth factor receptor pathway substrate 15
FAS Fas cell surface death receptor
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGKC immunoglobulin kappa constant
IRF8 interferon regulatory factor 8
KLHL6 kelch-like family member 6
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCD protein kinase C, delta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TRAF3IP2 TRAF3 interacting protein 2
VAV1 vav 1 guanine nucleotide exchange factor
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