increased interleukin-17 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors (Mammalian Phenotype Ontology, MP_0008681)
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28 gene mutations causing the increased interleukin-17 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BHLHE41 basic helix-loop-helix family, member e41
CLEC4D C-type lectin domain family 4, member D
CLEC6A C-type lectin domain family 6, member A
CTLA4 cytotoxic T-lymphocyte-associated protein 4
FLG filaggrin
GPR15 G protein-coupled receptor 15
HAVCR1 hepatitis A virus cellular receptor 1
IFNG interferon, gamma
IL10RB interleukin 10 receptor, beta
IL17RA interleukin 17 receptor A
IL17RC interleukin 17 receptor C
IL1RN interleukin 1 receptor antagonist
IL22 interleukin 22
MEFV Mediterranean fever
MMP1 matrix metallopeptidase 1
NCKAP1L NCK-associated protein 1-like
NFIL3 nuclear factor, interleukin 3 regulated
NLRP3 NLR family, pyrin domain containing 3
PLCD1 phospholipase C, delta 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
TBX21 T-box 21
THBS1 thrombospondin 1
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TSC22D3 TSC22 domain family, member 3
VTCN1 V-set domain containing T cell activation inhibitor 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa