increased interleukin-5 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells (Mammalian Phenotype Ontology, MP_0008702)
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21 gene mutations causing the increased interleukin-5 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATF3 activating transcription factor 3
CCR4 chemokine (C-C motif) receptor 4
CD300LF CD300 molecule-like family member f
CISH cytokine inducible SH2-containing protein
CTSE cathepsin E
FLG filaggrin
FYN FYN proto-oncogene, Src family tyrosine kinase
GPR34 G protein-coupled receptor 34
GPR84 G protein-coupled receptor 84
HAVCR1 hepatitis A virus cellular receptor 1
HCK HCK proto-oncogene, Src family tyrosine kinase
IFNG interferon, gamma
IL4 interleukin 4
MEFV Mediterranean fever
MMP9 matrix metallopeptidase 9
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
RAD50 RAD50 homolog (S. cerevisiae)
RGS16 regulator of G-protein signaling 16
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TSLP thymic stromal lymphopoietin