increased intestinal adenocarcinoma incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description higher than normal incidence of a malignant neoplasm of epithelial cells in the intestine (Mammalian Phenotype Ontology, MP_0002957)
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22 gene mutations causing the increased intestinal adenocarcinoma incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APC adenomatous polyposis coli
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DCC DCC netrin 1 receptor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IL10 interleukin 10
LIG4 ligase IV, DNA, ATP-dependent
LTBP4 latent transforming growth factor beta binding protein 4
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MUC2 mucin 2, oligomeric mucus/gel-forming
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPARD peroxisome proliferator-activated receptor delta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SSBP2 single-stranded DNA binding protein 2
TGFB1 transforming growth factor, beta 1
TNK1 tyrosine kinase, non-receptor, 1