increased leydig cell tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of rare testicular tumors of the male gonadal interstitium, occurring in a specific population in a given time period; Leydig cell tumors are frequently hormonally active, leading to feminizing or virilizing syndromes; Leydig cell tumors comprise 1-3% of all testicular neoplasms, can be pure or mixed with other sex cord-stromal or germ cell tumors, and are usually benign, although malignant variants also occur (Mammalian Phenotype Ontology, MP_0009592)
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3 gene mutations causing the increased leydig cell tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
MEN1 multiple endocrine neoplasia I
NBN nibrin