increased mast cell degranulation Gene Set

Dataset	MPO Gene-Phenotype Associations
Category	disease or phenotype associations
Type	phenotype
Description	increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell (Mammalian Phenotype Ontology, MP_0008764)
External Link	http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008764
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Genes

11 gene mutations causing the increased mast cell degranulation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol	Name
CCR3	chemokine (C-C motif) receptor 3
CORO1A	coronin, actin binding protein, 1A
DUSP1	dual specificity phosphatase 1
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LAT2	linker for activation of T cells family, member 2
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
MMP24	matrix metallopeptidase 24 (membrane-inserted)
NF1	neurofibromin 1
PLA2G4A	phospholipase A2, group IVA (cytosolic, calcium-dependent)
SPRED1	sprouty-related, EVH1 domain containing 1