increased mortality induced by gamma-irradiation Gene Set

Dataset MGI Mouse Phenotype Associations 2023
Category disease or phenotype associations
Type phenotype
Description greater sensitivity to doses of ionizing radiation (Mammalian Phenotype Ontology, MP_0001658)
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Genes

36 gene mutations causing the increased mortality induced by gamma-irradiation phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol Name
ABRAXAS1 abraxas 1, BRCA1 A complex subunit
ANG angiogenin, ribonuclease, RNase A family, 5
ATM ATM serine/threonine kinase
BRCA1 breast cancer 1, early onset
CCNG1 cyclin G1
COPS6 COP9 signalosome subunit 6
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
EWSR1 EWS RNA-binding protein 1
FUS FUS RNA binding protein
GPX4 glutathione peroxidase 4
H2AX H2A.X variant histone
HMGN1 high mobility group nucleosome binding domain 1
ING1 inhibitor of growth family, member 1
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KMT2E lysine (K)-specific methyltransferase 2E
MCPH1 microcephalin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MRE11 MRE11 homolog, double strand break repair nuclease
MUS81 MUS81 structure-specific endonuclease subunit
NABP2 nucleic acid binding protein 2
NBN nibrin
OCIAD1 OCIA domain containing 1
PARG poly (ADP-ribose) glycohydrolase
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PAXX PAXX non-homologous end joining factor
PER2 period circadian clock 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RBM38 RNA binding motif protein 38
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPL27A ribosomal protein L27a
SNAI2 snail family zinc finger 2
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
UIMC1 ubiquitin interaction motif containing 1
USP1 ubiquitin specific peptidase 1