increased regulatory T cell number Gene Set

Dataset MGI Mouse Phenotype Associations 2023
Category disease or phenotype associations
Type phenotype
Description greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity (Mammalian Phenotype Ontology, MP_0004973)
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Genes

22 gene mutations causing the increased regulatory T cell number phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol Name
BCL2L11 BCL2-like 11 (apoptosis facilitator)
CD247 CD247 molecule
CD5 CD5 molecule
CTSV cathepsin V
FGL2 fibrinogen-like 2
HBS1L HBS1-like translational GTPase
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1RL2 interleukin 1 receptor-like 2
IL2 interleukin 2
IL36G interleukin 36, gamma
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRRC8A leucine rich repeat containing 8 family, member A
MIR146A microRNA 146a
PDCD1 programmed cell death 1
PI16 peptidase inhibitor 16
PTGDR prostaglandin D2 receptor (DP)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
SETD5 SET domain containing 5
SYTL1 synaptotagmin-like 1
TGFB1 transforming growth factor, beta 1
TREX1 three prime repair exonuclease 1
TXNIP thioredoxin interacting protein