increased response of heart to induced stress Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding (Mammalian Phenotype Ontology, MP_0004485)
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31 gene mutations causing the increased response of heart to induced stress phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
APLN apelin
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
CASQ2 calsequestrin 2 (cardiac muscle)
FLT1 fms-related tyrosine kinase 1
GLRX3 glutaredoxin 3
GPR22 G protein-coupled receptor 22
HRC histidine rich calcium binding protein
INPP5F inositol polyphosphate-5-phosphatase F
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KLF15 Kruppel-like factor 15
LDB3 LIM domain binding 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK8 mitogen-activated protein kinase 8
MIR22 microRNA 22
MYBPC3 myosin binding protein C, cardiac
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYLK3 myosin light chain kinase 3
MYOZ2 myozenin 2
NEK6 NIMA-related kinase 6
NOX4 NADPH oxidase 4
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCE1 phospholipase C, epsilon 1
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RYR2 ryanodine receptor 2 (cardiac)
TCAP titin-cap
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TRPM2 transient receptor potential cation channel, subfamily M, member 2