increased sensitivity to induced morbidity/mortality Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decrease in the amount of an external agent required to cause death or diseased state (Mammalian Phenotype Ontology, MP_0009763)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009763
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Genes

273 gene mutations causing the increased sensitivity to induced morbidity/mortality phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACADVL acyl-CoA dehydrogenase, very long chain
ACE2 angiotensin I converting enzyme 2
ACHE acetylcholinesterase (Yt blood group)
ADAM17 ADAM metallopeptidase domain 17
ADGRV1 adhesion G protein-coupled receptor V1
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA2B adenosine A2b receptor
AGTR2 angiotensin II receptor, type 2
AHR aryl hydrocarbon receptor
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
AMACR alpha-methylacyl-CoA racemase
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARX aristaless related homeobox
ASGR1 asialoglycoprotein receptor 1
ASGR2 asialoglycoprotein receptor 2
ATF6 activating transcription factor 6
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BCHE butyrylcholinesterase
BCL3 B-cell CLL/lymphoma 3
BDKRB2 bradykinin receptor B2
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
C3 complement component 3
C3AR1 complement component 3a receptor 1
C4A complement component 4A (Rodgers blood group)
C5AR1 complement component 5a receptor 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CD19 CD19 molecule
CD226 CD226 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CERK ceramide kinase
CFP complement factor properdin
CLCN3 chloride channel, voltage-sensitive 3
CLEC4M C-type lectin domain family 4, member M
CLEC7A C-type lectin domain family 7, member A
CNR1 cannabinoid receptor 1 (brain)
CPA3 carboxypeptidase A3 (mast cell)
CPB2 carboxypeptidase B2 (plasma)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRLF2 cytokine receptor-like factor 2
CTH cystathionine gamma-lyase
CTNNA3 catenin (cadherin-associated protein), alpha 3
CUZD1 CUB and zona pellucida-like domains 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DOCK2 dedicator of cytokinesis 2
DUSP1 dual specificity phosphatase 1
EDN2 endothelin 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERCC1 excision repair cross-complementation group 1
ESR2 estrogen receptor 2 (ER beta)
F13A1 coagulation factor XIII, A1 polypeptide
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FABP3 fatty acid binding protein 3, muscle and heart
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAIM Fas apoptotic inhibitory molecule
FAS Fas cell surface death receptor
FFAR2 free fatty acid receptor 2
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PC3 glucose 6 phosphatase, catalytic, 3
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GLP2R glucagon-like peptide 2 receptor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPX3 glutathione peroxidase 3
GRM7 glutamate receptor, metabotropic 7
GSTA3 glutathione S-transferase alpha 3
GSTZ1 glutathione S-transferase zeta 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HCST hematopoietic cell signal transducer
HGFAC HGF activator
HMOX2 heme oxygenase 2
HP haptoglobin
HSPA1B heat shock 70kDa protein 1B
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
HTT huntingtin
IFIH1 interferon induced with helicase C domain 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL10 interleukin 10
IL12A interleukin 12A
IL12B interleukin 12B
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL27RA interleukin 27 receptor, alpha
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ING4 inhibitor of growth family, member 4
IP6K2 inositol hexakisphosphate kinase 2
IRF1 interferon regulatory factor 1
IRF8 interferon regulatory factor 8
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
IVNS1ABP influenza virus NS1A binding protein
JAM2 junctional adhesion molecule 2
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCP kielin/chordin-like protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KLF15 Kruppel-like factor 15
KLK8 kallikrein-related peptidase 8
LAMA4 laminin, alpha 4
LASP1 LIM and SH3 protein 1
LAT2 linker for activation of T cells family, member 2
LCN2 lipocalin 2
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LY75 lymphocyte antigen 75
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MARCO macrophage receptor with collagenous structure
MBOAT4 membrane bound O-acyltransferase domain containing 4
MBTPS1 membrane-bound transcription factor peptidase, site 1
MECOM MDS1 and EVI1 complex locus
MERTK MER proto-oncogene, tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR144 microRNA 144
MIR451A microRNA 451a
MLXIPL MLX interacting protein-like
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MST1R macrophage stimulating 1 receptor
MUC2 mucin 2, oligomeric mucus/gel-forming
MUS81 MUS81 structure-specific endonuclease subunit
MX1 MX dynamin-like GTPase 1
MYLK3 myosin light chain kinase 3
NCF1 neutrophil cytosolic factor 1
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRP6 NLR family, pyrin domain containing 6
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOTCH3 notch 3
NPAS4 neuronal PAS domain protein 4
NPY2R neuropeptide Y receptor Y2
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRG1 neuregulin 1
NRP2 neuropilin 2
OTC ornithine carbamoyltransferase
PARG poly (ADP-ribose) glycohydrolase
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDCD1LG2 programmed cell death 1 ligand 2
PENK proenkephalin
PEX7 peroxisomal biogenesis factor 7
PGAP3 post-GPI attachment to proteins 3
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PGLYRP3 peptidoglycan recognition protein 3
PGLYRP4 peptidoglycan recognition protein 4
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCL1 phospholipase C-like 1
PLG plasminogen
PNPLA6 patatin-like phospholipase domain containing 6
PNPLA8 patatin-like phospholipase domain containing 8
POSTN periostin, osteoblast specific factor
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRF1 perforin 1 (pore forming protein)
PROS1 protein S (alpha)
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALBP1 ralA binding protein 1
RB1 retinoblastoma 1
REG1B regenerating islet-derived 1 beta
RGN regucalcin
RGS4 regulator of G-protein signaling 4
RHBDD3 rhomboid domain containing 3
RHCG Rh family, C glycoprotein
RRAGA Ras-related GTP binding A
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
SCN5A sodium channel, voltage gated, type V alpha subunit
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SIRT2 sirtuin 2
SKIL SKI-like proto-oncogene
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SLPI secretory leukocyte peptidase inhibitor
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SOCS1 suppressor of cytokine signaling 1
SOD1 superoxide dismutase 1, soluble
SOD3 superoxide dismutase 3, extracellular
SPP1 secreted phosphoprotein 1
SRXN1 sulfiredoxin 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIP1 stress-induced phosphoprotein 1
TGM2 transglutaminase 2
THBD thrombomodulin
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNXB tenascin XB
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TPMT thiopurine S-methyltransferase
TRAFD1 TRAF-type zinc finger domain containing 1
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TSLP thymic stromal lymphopoietin
TXNIP thioredoxin interacting protein
UIMC1 ubiquitin interaction motif containing 1
UTRN utrophin
VASN vasorin
VCL vinculin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1
YIPF6 Yip1 domain family, member 6
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZNF148 zinc finger protein 148