increased sensitivity to xenobiotic induced morbidity/mortality Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decrease in the amount of a foreign compound required to cause death or diseased state (Mammalian Phenotype Ontology, MP_0009766)
External Link
Similar Terms
Downloads & Tools


109 gene mutations causing the increased sensitivity to xenobiotic induced morbidity/mortality phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACHE acetylcholinesterase (Yt blood group)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AHR aryl hydrocarbon receptor
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANXA1 annexin A1
APOD apolipoprotein D
ATF6 activating transcription factor 6
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BCHE butyrylcholinesterase
BLMH bleomycin hydrolase
BRCA1 breast cancer 1, early onset
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLEC4M C-type lectin domain family 4, member M
CNR1 cannabinoid receptor 1 (brain)
CPA3 carboxypeptidase A3 (mast cell)
CRLF2 cytokine receptor-like factor 2
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DOCK2 dedicator of cytokinesis 2
DUSP1 dual specificity phosphatase 1
ERCC1 excision repair cross-complementation group 1
FADS1 fatty acid desaturase 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAIM Fas apoptotic inhibitory molecule
FFAR2 free fatty acid receptor 2
FOXO3 forkhead box O3
FPR2 formyl peptide receptor 2
FYN FYN proto-oncogene, Src family tyrosine kinase
GCLM glutamate-cysteine ligase, modifier subunit
GLP2R glucagon-like peptide 2 receptor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GRM7 glutamate receptor, metabotropic 7
GSTA3 glutathione S-transferase alpha 3
HGFAC HGF activator
HP haptoglobin
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
HTT huntingtin
IFNG interferon, gamma
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL12A interleukin 12A
IL12B interleukin 12B
IL23A interleukin 23, alpha subunit p19
IL27RA interleukin 27 receptor, alpha
IL6ST interleukin 6 signal transducer
ING4 inhibitor of growth family, member 4
IP6K2 inositol hexakisphosphate kinase 2
IRF1 interferon regulatory factor 1
IVNS1ABP influenza virus NS1A binding protein
JAM2 junctional adhesion molecule 2
KCNK2 potassium channel, two pore domain subfamily K, member 2
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK8 kallikrein-related peptidase 8
LAT2 linker for activation of T cells family, member 2
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MBTPS1 membrane-bound transcription factor peptidase, site 1
MECOM MDS1 and EVI1 complex locus
MIR144 microRNA 144
MIR451A microRNA 451a
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MST1R macrophage stimulating 1 receptor
MUC2 mucin 2, oligomeric mucus/gel-forming
MUS81 MUS81 structure-specific endonuclease subunit
NFE2L2 nuclear factor, erythroid 2-like 2
NLRP6 NLR family, pyrin domain containing 6
NOD2 nucleotide-binding oligomerization domain containing 2
NPAS4 neuronal PAS domain protein 4
NPY2R neuropeptide Y receptor Y2
NRG1 neuregulin 1
PARG poly (ADP-ribose) glycohydrolase
PCSK1 proprotein convertase subtilisin/kexin type 1
PGLYRP1 peptidoglycan recognition protein 1
PGLYRP2 peptidoglycan recognition protein 2
PGLYRP3 peptidoglycan recognition protein 3
PGLYRP4 peptidoglycan recognition protein 4
PLCL1 phospholipase C-like 1
PNPLA6 patatin-like phospholipase domain containing 6
PPARG peroxisome proliferator-activated receptor gamma
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD54B RAD54 homolog B (S. cerevisiae)
RAD54L RAD54-like (S. cerevisiae)
RGS4 regulator of G-protein signaling 4
RHBDD3 rhomboid domain containing 3
RYR1 ryanodine receptor 1 (skeletal)
SDC4 syndecan 4
SIRT2 sirtuin 2
SKIL SKI-like proto-oncogene
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SOCS1 suppressor of cytokine signaling 1
SOD1 superoxide dismutase 1, soluble
SRXN1 sulfiredoxin 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TP53 tumor protein p53
TP53INP1 tumor protein p53 inducible nuclear protein 1
TPMT thiopurine S-methyltransferase
TSLP thymic stromal lymphopoietin
UIMC1 ubiquitin interaction motif containing 1
UTRN utrophin
VASN vasorin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
YIPF6 Yip1 domain family, member 6
ZNF148 zinc finger protein 148