increased susceptibility to bacterial infection induced morbidity/mortality Gene Set

Dataset MGI Mouse Phenotype Associations 2023
Category disease or phenotype associations
Type phenotype
Description increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria (Mammalian Phenotype Ontology, MP_0009788)
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Genes

90 gene mutations causing the increased susceptibility to bacterial infection induced morbidity/mortality phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol Name
ACE2 angiotensin I converting enzyme 2
ADAMDEC1 ADAM-like, decysin 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AICDA activation-induced cytidine deaminase
AIM2 absent in melanoma 2
ANK1 ankyrin 1, erythrocytic
APCS amyloid P component, serum
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C4B_2 complement component 4B (Chido blood group), copy 2
CAMP cathelicidin antimicrobial peptide
CAV1 caveolin 1, caveolae protein, 22kDa
CD1D CD1d molecule
CD274 CD274 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLEC12A C-type lectin domain family 12, member A
CLEC4D C-type lectin domain family 4, member D
CLEC4M C-type lectin domain family 4, member M
CR2 complement component (3d/Epstein Barr virus) receptor 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYRIB CYFIP related Rac1 interactor B
ELANE elastase, neutrophil expressed
FBXO7 F-box protein 7
FCMR Fc fragment of IgM receptor
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FPR1 formyl peptide receptor 1
GBP3 guanylate binding protein 3
GBP7 guanylate binding protein 7
GIF gastric intrinsic factor (vitamin B synthesis)
GPR15 G protein-coupled receptor 15
GSDMA gasdermin A
HAMP hepcidin antimicrobial peptide
HRH1 histamine receptor H1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL12B interleukin 12B
IL17RE interleukin 17 receptor E
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL36G interleukin 36, gamma
IL6 interleukin 6
JAK3 Janus kinase 3
LIF leukemia inhibitory factor
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MIR146A microRNA 146a
MIR4435-2HG MIR4435-2 host gene
MSR1 macrophage scavenger receptor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NCOA3 nuclear receptor coactivator 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC4 NLR family, CARD domain containing 4
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
PGLYRP1 peptidoglycan recognition protein 1
PIAS1 protein inhibitor of activated STAT, 1
PILRB paired immunoglobin-like type 2 receptor beta
PKLR pyruvate kinase, liver and RBC
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RORC RAR-related orphan receptor C
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLAMF6 SLAM family member 6
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLFN12L schlafen family member 12-like
SNX8 sorting nexin 8
SP140L SP140 nuclear body protein-like
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
STK38 serine/threonine kinase 38
TBK1 TANK-binding kinase 1
TFPI2 tissue factor pathway inhibitor 2
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIM38 tripartite motif containing 38
TRIM8 tripartite motif containing 8
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV2 transient receptor potential cation channel, subfamily V, member 2
ZNF292 zinc finger protein 292