increased susceptibility to bacterial infection induced morbidity/mortality Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria (Mammalian Phenotype Ontology, MP_0009788)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009788
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Genes

71 gene mutations causing the increased susceptibility to bacterial infection induced morbidity/mortality phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AICDA activation-induced cytidine deaminase
AIM2 absent in melanoma 2
ANK1 ankyrin 1, erythrocytic
APCS amyloid P component, serum
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
CAMP cathelicidin antimicrobial peptide
CAV1 caveolin 1, caveolae protein, 22kDa
CD1D CD1d molecule
CD274 CD274 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CLEC4D C-type lectin domain family 4, member D
CR2 complement component (3d/Epstein Barr virus) receptor 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DUSP1 dual specificity phosphatase 1
ELANE elastase, neutrophil expressed
FBXO7 F-box protein 7
FCMR Fc fragment of IgM receptor
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FPR1 formyl peptide receptor 1
GBP3 guanylate binding protein 3
GPR15 G protein-coupled receptor 15
HAMP hepcidin antimicrobial peptide
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL12B interleukin 12B
IL17RE interleukin 17 receptor E
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL6 interleukin 6
IRF1 interferon regulatory factor 1
JAK3 Janus kinase 3
LIF leukemia inhibitory factor
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MSR1 macrophage scavenger receptor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYD88 myeloid differentiation primary response 88
NCOA3 nuclear receptor coactivator 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
PGLYRP1 peptidoglycan recognition protein 1
PIAS1 protein inhibitor of activated STAT, 1
PILRA paired immunoglobin-like type 2 receptor alpha
PKLR pyruvate kinase, liver and RBC
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RORC RAR-related orphan receptor C
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLAMF6 SLAM family member 6
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT4 signal transducer and activator of transcription 4
TBK1 TANK-binding kinase 1
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TREX1 three prime repair exonuclease 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV2 transient receptor potential cation channel, subfamily V, member 2
USP18 ubiquitin specific peptidase 18