increased susceptibility to endotoxin shock Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death (Mammalian Phenotype Ontology, MP_0008735)
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53 gene mutations causing the increased susceptibility to endotoxin shock phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATF2 activating transcription factor 2
BCR breakpoint cluster region
C3AR1 complement component 3a receptor 1
CASP12 caspase 12 (gene/pseudogene)
CMKLR1 chemerin chemokine-like receptor 1
DUSP1 dual specificity phosphatase 1
FES FES proto-oncogene, tyrosine kinase
FOS FBJ murine osteosarcoma viral oncogene homolog
GFI1 growth factor independent 1 transcription repressor
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IL10 interleukin 10
IL1RN interleukin 1 receptor antagonist
IL22 interleukin 22
IL6ST interleukin 6 signal transducer
IRAK3 interleukin-1 receptor-associated kinase 3
JUND jun D proto-oncogene
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
LAT2 linker for activation of T cells family, member 2
LEP leptin
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
MEFV Mediterranean fever
MERTK MER proto-oncogene, tyrosine kinase
MST1R macrophage stimulating 1 receptor
NCOA3 nuclear receptor coactivator 3
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NLRC3 NLR family, CARD domain containing 3
NLRX1 NLR family member X1
OTC ornithine carbamoyltransferase
PARG poly (ADP-ribose) glycohydrolase
PCSK1 proprotein convertase subtilisin/kexin type 1
PIAS1 protein inhibitor of activated STAT, 1
PILRA paired immunoglobin-like type 2 receptor alpha
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RCAN1 regulator of calcineurin 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLPI secretory leukocyte peptidase inhibitor
SRXN1 sulfiredoxin 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBK1 TANK-binding kinase 1
THBD thrombomodulin
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRAFD1 TRAF-type zinc finger domain containing 1
TREML1 triggering receptor expressed on myeloid cells-like 1
USP18 ubiquitin specific peptidase 18