increased susceptibility to induced morbidity/mortality Gene Set

Dataset MGI Mouse Phenotype Associations 2023
Category disease or phenotype associations
Type phenotype
Description decrease in the amount of an external agent required to cause death or diseased state (Medical Subject Headings)
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Genes

209 gene mutations causing the increased susceptibility to induced morbidity/mortality phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol Name
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACADVL acyl-CoA dehydrogenase, very long chain
ACE2 angiotensin I converting enzyme 2
ADAM17 ADAM metallopeptidase domain 17
ADAM28 ADAM metallopeptidase domain 28
ADGRV1 adhesion G protein-coupled receptor V1
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA2B adenosine A2b receptor
AGTR2 angiotensin II receptor, type 2
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOB aldolase B, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
ANGPTL4 angiopoietin-like 4
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARX aristaless related homeobox
ASGR1 asialoglycoprotein receptor 1
ASGR2 asialoglycoprotein receptor 2
ATG3 autophagy related 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BCL3 B-cell CLL/lymphoma 3
BDKRB2 bradykinin receptor B2
C1QTNF4 C1q and tumor necrosis factor related protein 4
C3 complement component 3
C3AR1 complement component 3a receptor 1
C4B_2 complement component 4B (Chido blood group), copy 2
C5AR1 complement component 5a receptor 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CD19 CD19 molecule
CD226 CD226 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CERK ceramide kinase
CFP complement factor properdin
CLCN3 chloride channel, voltage-sensitive 3
CLEC7A C-type lectin domain family 7, member A
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNR1 cannabinoid receptor 1 (brain)
CPA3 carboxypeptidase A3 (mast cell)
CPB2 carboxypeptidase B2 (plasma)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CSNK1G2 casein kinase 1, gamma 2
CTH cystathionine gamma-lyase
CTNNA3 catenin (cadherin-associated protein), alpha 3
CUZD1 CUB and zona pellucida-like domains 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DSG2 desmoglein 2
DUSP1 dual specificity phosphatase 1
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
EDIL3 EGF-like repeats and discoidin I-like domains 3
EDN2 endothelin 2
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
ESR2 estrogen receptor 2 (ER beta)
F13A1 coagulation factor XIII, A1 polypeptide
F8 coagulation factor VIII, procoagulant component
F9 coagulation factor IX
FABP3 fatty acid binding protein 3, muscle and heart
FADS2 fatty acid desaturase 2
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAM3A family with sequence similarity 3, member A
FAS Fas cell surface death receptor
FKBPL FK506 binding protein like
FNDC5 fibronectin type III domain containing 5
FOXE3 forkhead box E3
FOXP3 forkhead box P3
G6PC3 glucose 6 phosphatase, catalytic, 3
GALT galactose-1-phosphate uridylyltransferase
GDF15 growth differentiation factor 15
GPX3 glutathione peroxidase 3
GSTZ1 glutathione S-transferase zeta 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
HCST hematopoietic cell signal transducer
HMOX2 heme oxygenase 2
HSPA1B heat shock 70kDa protein 1B
HSPA4L heat shock 70kDa protein 4-like
HSPB8 heat shock 22kDa protein 8
IFIH1 interferon induced with helicase C domain 1
IFNGR1 interferon gamma receptor 1
IL10 interleukin 10
IL25 interleukin 25
IL6 interleukin 6
IRF8 interferon regulatory factor 8
ITGB1BP2 integrin beta 1 binding protein (melusin) 2
KCNIP1 Kv channel interacting protein 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCP kielin/chordin-like protein
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KLF15 Kruppel-like factor 15
KLHL22 kelch-like family member 22
LAMA4 laminin, alpha 4
LASP1 LIM and SH3 protein 1
LCN2 lipocalin 2
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LOX lysyl oxidase
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LY75-CD302 LY75-CD302 readthrough
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MARCO macrophage receptor with collagenous structure
MBOAT4 membrane bound O-acyltransferase domain containing 4
MERTK MER proto-oncogene, tyrosine kinase
METRNL meteorin, glial cell differentiation regulator-like
MGMT O-6-methylguanine-DNA methyltransferase
MICU2 mitochondrial calcium uptake 2
MIR139 microRNA 139
MIR145 microRNA 145
MLXIPL MLX interacting protein-like
MPO myeloperoxidase
MYLK3 myosin light chain kinase 3
NCF1C neutrophil cytosolic factor 1C pseudogene
NFE2 nuclear factor, erythroid 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NOS2 nitric oxide synthase 2, inducible
NOTCH3 notch 3
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1H4 nuclear receptor subfamily 1, group H, member 4
NRP2 neuropilin 2
OTC ornithine carbamoyltransferase
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PDCD1LG2 programmed cell death 1 ligand 2
PENK proenkephalin
PEX7 peroxisomal biogenesis factor 7
PGAP3 post-GPI attachment to proteins 3
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLG plasminogen
PLIN5 perilipin 5
PNPLA8 patatin-like phospholipase domain containing 8
POLR2M polymerase (RNA) II (DNA directed) polypeptide M
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
PPARA peroxisome proliferator-activated receptor alpha
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRF1 perforin 1 (pore forming protein)
PROS1 protein S (alpha)
PROZ protein Z, vitamin K-dependent plasma glycoprotein
PTEN phosphatase and tensin homolog
PZP pregnancy-zone protein
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALBP1 ralA binding protein 1
RB1 retinoblastoma 1
REG1B regenerating islet-derived 1 beta
RGN regucalcin
RHCG Rh family, C glycoprotein
RRAGA Ras-related GTP binding A
RYR1 ryanodine receptor 1 (skeletal)
RYR2 ryanodine receptor 2 (cardiac)
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SOD3 superoxide dismutase 3, extracellular
SPP1 secreted phosphoprotein 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIP1 stress-induced phosphoprotein 1
STK38 serine/threonine kinase 38
STRIP2 striatin interacting protein 2
TGM2 transglutaminase 2
THBD thrombomodulin
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TMPRSS11F transmembrane protease, serine 11F
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNXB tenascin XB
TOR1A torsin family 1, member A (torsin A)
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM8 tripartite motif containing 8
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TXNIP thioredoxin interacting protein
VCL vinculin
VIM vimentin
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WIF1 WNT inhibitory factor 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta