increased susceptibility to infection induced morbidity/mortality Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens (Mammalian Phenotype Ontology, MP_0009787)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009787
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Genes

108 gene mutations causing the increased susceptibility to infection induced morbidity/mortality phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AICDA activation-induced cytidine deaminase
AIM2 absent in melanoma 2
ANK1 ankyrin 1, erythrocytic
APCS amyloid P component, serum
AQP4 aquaporin 4
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B2M beta-2-microglobulin
BATF2 basic leucine zipper transcription factor, ATF-like 2
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
CAMP cathelicidin antimicrobial peptide
CAV1 caveolin 1, caveolae protein, 22kDa
CCL13 chemokine (C-C motif) ligand 13
CCR2 chemokine (C-C motif) receptor 2
CD1D CD1d molecule
CD274 CD274 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CLEC4D C-type lectin domain family 4, member D
CLEC6A C-type lectin domain family 6, member A
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTSG cathepsin G
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
DUSP1 dual specificity phosphatase 1
ELANE elastase, neutrophil expressed
FBXO7 F-box protein 7
FCMR Fc fragment of IgM receptor
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FLT3 fms-related tyrosine kinase 3
FOXN1 forkhead box N1
FPR1 formyl peptide receptor 1
GBP2 guanylate binding protein 2, interferon-inducible
GBP3 guanylate binding protein 3
GPR15 G protein-coupled receptor 15
HAMP hepcidin antimicrobial peptide
HMOX1 heme oxygenase 1
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFITM3 interferon induced transmembrane protein 3
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL12B interleukin 12B
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL17RE interleukin 17 receptor E
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL27 interleukin 27
IL34 interleukin 34
IL4 interleukin 4
IL6 interleukin 6
IRF1 interferon regulatory factor 1
JAK3 Janus kinase 3
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
LIF leukemia inhibitory factor
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAVS mitochondrial antiviral signaling protein
MB21D1 Mab-21 domain containing 1
MMP9 matrix metallopeptidase 9
MSR1 macrophage scavenger receptor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MX1 MX dynamin-like GTPase 1
MYD88 myeloid differentiation primary response 88
NCOA3 nuclear receptor coactivator 3
NCR1 natural cytotoxicity triggering receptor 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
PGLYRP1 peptidoglycan recognition protein 1
PIAS1 protein inhibitor of activated STAT, 1
PILRA paired immunoglobin-like type 2 receptor alpha
PKLR pyruvate kinase, liver and RBC
PRF1 perforin 1 (pore forming protein)
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RORC RAR-related orphan receptor C
SARM1 sterile alpha and TIR motif containing 1
SELK selenoprotein K
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SFN stratifin
SLAMF6 SLAM family member 6
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT4 signal transducer and activator of transcription 4
TBK1 TANK-binding kinase 1
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMEM173 transmembrane protein 173
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TREX1 three prime repair exonuclease 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TYK2 tyrosine kinase 2
USP18 ubiquitin specific peptidase 18