increased susceptibility to ischemic brain injury Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased frequency or more severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of all or part of the brain tissue, compared to controls (Mammalian Phenotype Ontology, MP_0003076)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003076
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Genes

28 gene mutations causing the increased susceptibility to ischemic brain injury phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAV1 caveolin 1, caveolae protein, 22kDa
CD1D CD1d molecule
CNR1 cannabinoid receptor 1 (brain)
CNTF ciliary neurotrophic factor
CST3 cystatin C
DCR Down syndrome chromosome region
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAIM2 Fas apoptotic inhibitory molecule 2
GPX1 glutathione peroxidase 1
GSN gelsolin
HSPA1B heat shock 70kDa protein 1B
HYOU1 hypoxia up-regulated 1
IL10 interleukin 10
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein
KCNK2 potassium channel, two pore domain subfamily K, member 2
NDRG4 NDRG family member 4
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NFE2L2 nuclear factor, erythroid 2-like 2
NOTCH3 notch 3
PSPN persephin
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
STIP1 stress-induced phosphoprotein 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
UNG uracil-DNA glycosylase
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