increased susceptibility to type i hypersensitivity reaction Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks (Mammalian Phenotype Ontology, MP_0005596)
External Link
Similar Terms
Downloads & Tools


33 gene mutations causing the increased susceptibility to type i hypersensitivity reaction phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
C3AR1 complement component 3a receptor 1
CD28 CD28 molecule
CD300LF CD300 molecule-like family member f
CISH cytokine inducible SH2-containing protein
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FYN FYN proto-oncogene, Src family tyrosine kinase
HPGDS hematopoietic prostaglandin D synthase
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL13 interleukin 13
IL25 interleukin 25
IL4R interleukin 4 receptor
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LPAR2 lysophosphatidic acid receptor 2
MILR1 mast cell immunoglobulin-like receptor 1
MME membrane metallo-endopeptidase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PTAFR platelet-activating factor receptor
PTGDR2 prostaglandin D2 receptor 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGES prostaglandin E synthase
PTGES2 prostaglandin E synthase 2
RGS13 regulator of G-protein signaling 13
RGS3 regulator of G-protein signaling 3
TBXA2R thromboxane A2 receptor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRPM4 transient receptor potential cation channel, subfamily M, member 4