increased susceptibility to type iv hypersensitivity reaction Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact (Mammalian Phenotype Ontology, MP_0005617)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005617
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Genes

19 gene mutations causing the increased susceptibility to type iv hypersensitivity reaction phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CCR1 chemokine (C-C motif) receptor 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
F11R F11 receptor
FBN1 fibrillin 1
FLG filaggrin
FOXP3 forkhead box P3
GPR34 G protein-coupled receptor 34
IFNG interferon, gamma
IL10 interleukin 10
IL20RB interleukin 20 receptor beta
IL27 interleukin 27
MMP9 matrix metallopeptidase 9
NLRP3 NLR family, pyrin domain containing 3
PLA2G2D phospholipase A2, group IID
SSTR4 somatostatin receptor 4
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TSC22D3 TSC22 domain family, member 3
VIPR2 vasoactive intestinal peptide receptor 2
Funding