increased thymocyte apoptosis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increase in the number of immature T cells located in the thymus that are undergoing programmed cell death (Mammalian Phenotype Ontology, MP_0009541)
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22 gene mutations causing the increased thymocyte apoptosis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BIRC6 baculoviral IAP repeat containing 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
COPS6 COP9 signalosome subunit 6
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
FAIM Fas apoptotic inhibitory molecule
IL15RA interleukin 15 receptor, alpha
ING1 inhibitor of growth family, member 1
KIFAP3 kinesin-associated protein 3
NHEJ1 nonhomologous end-joining factor 1
PNP purine nucleoside phosphorylase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RUNX1 runt-related transcription factor 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP73 tumor protein p73
TRAF2 TNF receptor-associated factor 2
TWSG1 twisted gastrulation BMP signaling modulator 1
USP4 ubiquitin specific peptidase 4 (proto-oncogene)