increased tumor necrosis factor secretion Gene Set

Dataset MGI Mouse Phenotype Associations 2023
Category disease or phenotype associations
Type phenotype
Description increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium (Mammalian Phenotype Ontology, MP_0008560)
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Genes

112 gene mutations causing the increased tumor necrosis factor secretion phenotype in transgenic mice from the MGI Mouse Phenotype Associations 2023 dataset.

Symbol Name
ADORA2B adenosine A2b receptor
ADRB2 adrenoceptor beta 2, surface
AIM2 absent in melanoma 2
AIRE autoimmune regulator
APOE apolipoprotein E
ARHGAP17 Rho GTPase activating protein 17
ARRB2 arrestin, beta 2
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
B2M beta-2-microglobulin
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BPIFA1 BPI fold containing family A, member 1
C1QTNF4 C1q and tumor necrosis factor related protein 4
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CD200R1L CD200 receptor 1-like
CD274 CD274 molecule
CD300A CD300a molecule
CD44 CD44 molecule (Indian blood group)
CLEC12A C-type lectin domain family 12, member A
CLEC4D C-type lectin domain family 4, member D
CLEC6A C-type lectin domain family 6, member A
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
DMD dystrophin
DPP3 dipeptidyl-peptidase 3
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EBF1 early B-cell factor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FYN FYN proto-oncogene, Src family tyrosine kinase
GFI1 growth factor independent 1 transcription repressor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR108 G protein-coupled receptor 108
GPR34 G protein-coupled receptor 34
GRN granulin
GSTCD glutathione S-transferase, C-terminal domain containing
HAVCR1 hepatitis A virus cellular receptor 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSF1 heat shock transcription factor 1
IDO1 indoleamine 2,3-dioxygenase 1
IFNB1 interferon, beta 1, fibroblast
IFNGR1 interferon gamma receptor 1
IL17B interleukin 17B
IL19 interleukin 19
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
IRAK3 interleukin-1 receptor-associated kinase 3
KLRC4 killer cell lectin-like receptor subfamily C, member 4
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR2 lysophosphatidic acid receptor 2
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MERTK MER proto-oncogene, tyrosine kinase
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIR146A microRNA 146a
MIR425 microRNA 425
MMP28 matrix metallopeptidase 28
MUC2 mucin 2, oligomeric mucus/gel-forming
N4BP1 NEDD4 binding protein 1
NCKAP1L NCK-associated protein 1-like
NCOA3 nuclear receptor coactivator 3
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRC3 NLR family, CARD domain containing 3
NLRP1 NLR family, pyrin domain containing 1
NUCB2 nucleobindin 2
PBK PDZ binding kinase
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
POMC proopiomelanocortin
PRDX5 peroxiredoxin 5
PRF1 perforin 1 (pore forming protein)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYCARD PYD and CARD domain containing
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RC3H2 ring finger and CCCH-type domains 2
RNF20 ring finger protein 20, E3 ubiquitin protein ligase
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SH3BP2 SH3-domain binding protein 2
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8
SOCS2 suppressor of cytokine signaling 2
SOD1 superoxide dismutase 1, soluble
SOD3 superoxide dismutase 3, extracellular
SSTR4 somatostatin receptor 4
STK17B serine/threonine kinase 17b
STK38 serine/threonine kinase 38
STX11 syntaxin 11
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TBK1 TANK-binding kinase 1
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TIMP3 TIMP metallopeptidase inhibitor 3
TNF tumor necrosis factor
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNIP1 TNFAIP3 interacting protein 1
TRAFD1 TRAF-type zinc finger domain containing 1
TREML1 triggering receptor expressed on myeloid cells-like 1
TRIM27 tripartite motif containing 27
TRIM8 tripartite motif containing 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UNC93B1 unc-93 homolog B1 (C. elegans)
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
WDR41 WD repeat domain 41
ZC3H12A zinc finger CCCH-type containing 12A