increased type ii pneumocyte number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored (Mammalian Phenotype Ontology, MP_0010810)
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12 gene mutations causing the increased type ii pneumocyte number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
BMPER BMP binding endothelial regulator
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
ERRFI1 ERBB receptor feedback inhibitor 1
FSTL1 follistatin-like 1
GLI2 GLI family zinc finger 2
HOXA5 homeobox A5
IGF1 insulin-like growth factor 1 (somatomedin C)
LIPA lipase A, lysosomal acid, cholesterol esterase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
SFTPC surfactant protein C
SFTPD surfactant protein D