indapamide-3778 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the indapamide-3778 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACE angiotensin I converting enzyme
ADGB androglobin
AGXT alanine-glyoxylate aminotransferase
AKAP6 A kinase (PRKA) anchor protein 6
APOB apolipoprotein B
APOD apolipoprotein D
APOE apolipoprotein E
ATP10A ATPase, class V, type 10A
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BBC3 BCL2 binding component 3
C14ORF1 chromosome 14 open reading frame 1
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CALCA calcitonin-related polypeptide alpha
CAMK1G calcium/calmodulin-dependent protein kinase IG
CARTPT CART prepropeptide
CASC1 cancer susceptibility candidate 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DRP2 dystrophin related protein 2
DUOX1 dual oxidase 1
EGFL7 EGF-like-domain, multiple 7
EPX eosinophil peroxidase
ESR1 estrogen receptor 1
EVI2B ecotropic viral integration site 2B
EXOSC1 exosome component 1
EXTL1 exostosin-like glycosyltransferase 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FBXO40 F-box protein 40
FGF12 fibroblast growth factor 12
FGFR2 fibroblast growth factor receptor 2
FOSL2 FOS-like antigen 2
FOXL1 forkhead box L1
FRY furry homolog (Drosophila)
GFI1 growth factor independent 1 transcription repressor
GHRHR growth hormone releasing hormone receptor
GP2 glycoprotein 2 (zymogen granule membrane)
GPC3 glypican 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HRG histidine-rich glycoprotein
HSPB3 heat shock 27kDa protein 3
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
ID2B inhibitor of DNA binding 2B, dominant negative helix-loop-helix protein (pseudogene)
IL1RN interleukin 1 receptor antagonist
ING4 inhibitor of growth family, member 4
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KANK3 KN motif and ankyrin repeat domains 3
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KIF1A kinesin family member 1A
LINC00216 long intergenic non-protein coding RNA 216
LRRC36 leucine rich repeat containing 36
MCF2L MCF.2 cell line derived transforming sequence-like
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP3 microfibrillar-associated protein 3
MSLN mesothelin
MTMR1 myotubularin related protein 1
MTSS1L metastasis suppressor 1-like
MUC6 mucin 6, oligomeric mucus/gel-forming
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
NEK1 NIMA-related kinase 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NNAT neuronatin
NPR1 natriuretic peptide receptor 1
PAPPA2 pappalysin 2
PAX8 paired box 8
PECAM1 platelet/endothelial cell adhesion molecule 1
PIGR polymeric immunoglobulin receptor
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PTEN phosphatase and tensin homolog
RAB40A RAB40A, member RAS oncogene family
RIMS2 regulating synaptic membrane exocytosis 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SCN1B sodium channel, voltage gated, type I beta subunit
SHOX2 short stature homeobox 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SNED1 sushi, nidogen and EGF-like domains 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPAG11B sperm associated antigen 11B
SPPL2B signal peptide peptidase like 2B
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAS2R1 taste receptor, type 2, member 1
TAT tyrosine aminotransferase
TECTA tectorin alpha
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TSGA10 testis specific, 10
UBA6 ubiquitin-like modifier activating enzyme 6
WNT1 wingless-type MMTV integration site family, member 1
WNT8B wingless-type MMTV integration site family, member 8B
ZBED2 zinc finger, BED-type containing 2
ZBTB7A zinc finger and BTB domain containing 7A
ZFAND6 zinc finger, AN1-type domain 6

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADCY6 adenylate cyclase 6
ADTRP androgen-dependent TFPI-regulating protein
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARMC4 armadillo repeat containing 4
B9D2 B9 protein domain 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BDKRB1 bradykinin receptor B1
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
CBX4 chromobox homolog 4
CCDC186 coiled-coil domain containing 186
CCDC9 coiled-coil domain containing 9
CHM choroideremia (Rab escort protein 1)
CLCN5 chloride channel, voltage-sensitive 5
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COBL cordon-bleu WH2 repeat protein
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CPNE7 copine VII
CTSO cathepsin O
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DCAF4 DDB1 and CUL4 associated factor 4
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM120C family with sequence similarity 120C
FAM204A family with sequence similarity 204, member A
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKBP10 FK506 binding protein 10, 65 kDa
FMOD fibromodulin
GALT galactose-1-phosphate uridylyltransferase
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GK3P glycerol kinase 3 pseudogene
GMEB1 glucocorticoid modulatory element binding protein 1
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRAMD1C GRAM domain containing 1C
GTF2I general transcription factor IIi
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H4D histone cluster 1, H4d
HOXB2 homeobox B2
HOXC11 homeobox C11
HSPA1L heat shock 70kDa protein 1-like
IFI6 interferon, alpha-inducible protein 6
IFNA17 interferon, alpha 17
IFT81 intraflagellar transport 81
INO80D INO80 complex subunit D
IPO8 importin 8
IQCG IQ motif containing G
KCTD20 potassium channel tetramerization domain containing 20
KRT8P12 keratin 8 pseudogene 12
LAMC3 laminin, gamma 3
LIFR leukemia inhibitory factor receptor alpha
LMNB1 lamin B1
LRRC15 leucine rich repeat containing 15
MLYCD malonyl-CoA decarboxylase
MRPS34 mitochondrial ribosomal protein S34
MTERF4 mitochondrial transcription termination factor 4
NABP1 nucleic acid binding protein 1
NEK11 NIMA-related kinase 11
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NID2 nidogen 2 (osteonidogen)
NLGN1 neuroligin 1
NPM3 nucleophosmin/nucleoplasmin 3
NUP62CL nucleoporin 62kDa C-terminal like
PADI1 peptidyl arginine deiminase, type I
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PLAC8 placenta-specific 8
PLD2 phospholipase D2
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PPL periplakin
PTPRS protein tyrosine phosphatase, receptor type, S
PWAR5 Prader Willi/Angelman region RNA 5
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF146 ring finger protein 146
RWDD2A RWD domain containing 2A
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SCAI suppressor of cancer cell invasion
SETD6 SET domain containing 6
SETD8 SET domain containing (lysine methyltransferase) 8
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TLR2 toll-like receptor 2
TMEM242 transmembrane protein 242
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
URGCP upregulator of cell proliferation
VEZT vezatin, adherens junctions transmembrane protein
WDR25 WD repeat domain 25
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF230 zinc finger protein 230
ZNF671 zinc finger protein 671
ZNF747 zinc finger protein 747
ZNF83 zinc finger protein 83