indapamide-4335 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the indapamide-4335 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ACVR1B activin A receptor, type IB
ADAM12 ADAM metallopeptidase domain 12
APC2 adenomatosis polyposis coli 2
AQP6 aquaporin 6, kidney specific
ARHGAP28 Rho GTPase activating protein 28
ARTN artemin
ASPN asporin
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BICD1 bicaudal D homolog 1 (Drosophila)
BMP7 bone morphogenetic protein 7
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CEP41 centrosomal protein 41kDa
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLEC4E C-type lectin domain family 4, member E
CNTN5 contactin 5
CNTNAP2 contactin associated protein-like 2
COPE coatomer protein complex, subunit epsilon
CRAT carnitine O-acetyltransferase
CTNS cystinosin, lysosomal cystine transporter
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCTN1 dynactin 1
DKFZP434C153 DKFZP434C153 protein
DNAAF1 dynein, axonemal, assembly factor 1
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
ELAVL3 ELAV like neuron-specific RNA binding protein 3
EPAS1 endothelial PAS domain protein 1
FBXO31 F-box protein 31
GBP2 guanylate binding protein 2, interferon-inducible
GOLGA8A golgin A8 family, member A
GRIK5 glutamate receptor, ionotropic, kainate 5
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIST1H4C histone cluster 1, H4c
HNF4A hepatocyte nuclear factor 4, alpha
HOPX HOP homeobox
HRG histidine-rich glycoprotein
IL11 interleukin 11
IL12RB1 interleukin 12 receptor, beta 1
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
ING2 inhibitor of growth family, member 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LGALS14 lectin, galactoside-binding, soluble, 14
LOC100294391 uncharacterized LOC100294391
LRRC48 leucine rich repeat containing 48
LRRC75B leucine rich repeat containing 75B
MAPK8 mitogen-activated protein kinase 8
MED18 mediator complex subunit 18
MED25 mediator complex subunit 25
MET MET proto-oncogene, receptor tyrosine kinase
MMP11 matrix metallopeptidase 11
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NFIB nuclear factor I/B
NPEPPS aminopeptidase puromycin sensitive
NPTX1 neuronal pentraxin I
NT5M 5',3'-nucleotidase, mitochondrial
NTS neurotensin
NUMA1 nuclear mitotic apparatus protein 1
ONECUT2 one cut homeobox 2
PASK PAS domain containing serine/threonine kinase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM3 PDZ and LIM domain 3
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRB4 proline-rich protein BstNI subfamily 4
PRTN3 proteinase 3
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
RAP2A RAP2A, member of RAS oncogene family
RNF122 ring finger protein 122
RNF17 ring finger protein 17
RPL10 ribosomal protein L10
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SAYSD1 SAYSVFN motif domain containing 1
SF1 splicing factor 1
SFTPB surfactant protein B
SIRPB1 signal-regulatory protein beta 1
SIRT4 sirtuin 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
THRA thyroid hormone receptor, alpha
TIMP3 TIMP metallopeptidase inhibitor 3
TLDC1 TBC/LysM-associated domain containing 1
TRIL TLR4 interactor with leucine-rich repeats
TSC22D2 TSC22 domain family, member 2
TSGA10 testis specific, 10
USP22 ubiquitin specific peptidase 22
WIZ widely interspaced zinc finger motifs
WNT3 wingless-type MMTV integration site family, member 3
ZBTB7A zinc finger and BTB domain containing 7A
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTC1 actin, alpha, cardiac muscle 1
ADAM23 ADAM metallopeptidase domain 23
ADGRB2 adhesion G protein-coupled receptor B2
ADTRP androgen-dependent TFPI-regulating protein
AFF4 AF4/FMR2 family, member 4
AHDC1 AT hook, DNA binding motif, containing 1
ANKRD40 ankyrin repeat domain 40
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARRB2 arrestin, beta 2
ARSB arylsulfatase B
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BTBD2 BTB (POZ) domain containing 2
CCDC85C coiled-coil domain containing 85C
CDK6 cyclin-dependent kinase 6
CDKL3 cyclin-dependent kinase-like 3
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CNOT3 CCR4-NOT transcription complex, subunit 3
CPNE7 copine VII
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOCK1 dedicator of cytokinesis 1
EFHD2 EF-hand domain family, member D2
EIF5A2 eukaryotic translation initiation factor 5A2
ELMO3 engulfment and cell motility 3
ERCC2 excision repair cross-complementation group 2
ESRRG estrogen-related receptor gamma
FGL1 fibrinogen-like 1
FKBP5 FK506 binding protein 5
FLJ21369 uncharacterized protein FLJ21369
FSTL3 follistatin-like 3 (secreted glycoprotein)
GAN gigaxonin
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRAMD4 GRAM domain containing 4
GTF2IRD1 GTF2I repeat domain containing 1
HIST1H2BO histone cluster 1, H2bo
HLA-DMA major histocompatibility complex, class II, DM alpha
HOMER2 homer scaffolding protein 2
IFNA14 interferon, alpha 14
IL2 interleukin 2
ITPKA inositol-trisphosphate 3-kinase A
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLC2 kinesin light chain 2
LATS1 large tumor suppressor kinase 1
LIMS2 LIM and senescent cell antigen-like domains 2
LRRC61 leucine rich repeat containing 61
LYRM9 LYR motif containing 9
MICU1 mitochondrial calcium uptake 1
MXRA8 matrix-remodelling associated 8
MYH15 myosin, heavy chain 15
NKX3-2 NK3 homeobox 2
NPFFR1 neuropeptide FF receptor 1
ODF2 outer dense fiber of sperm tails 2
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OSGIN1 oxidative stress induced growth inhibitor 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PICK1 protein interacting with PRKCA 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PILRB paired immunoglobin-like type 2 receptor beta
PLAC1 placenta-specific 1
PLSCR2 phospholipid scramblase 2
PLXNB3 plexin B3
POLM polymerase (DNA directed), mu
POM121 POM121 transmembrane nucleoporin
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRSS53 protease, serine, 53
PRSS8 protease, serine, 8
PSKH1 protein serine kinase H1
PTPRU protein tyrosine phosphatase, receptor type, U
RABL6 RAB, member RAS oncogene family-like 6
RHOBTB2 Rho-related BTB domain containing 2
RUNX1-IT1 RUNX1 intronic transcript 1
SAMD9 sterile alpha motif domain containing 9
SBNO2 strawberry notch homolog 2 (Drosophila)
SENP7 SUMO1/sentrin specific peptidase 7
SH3GL1 SH3-domain GRB2-like 1
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SSBP3 single stranded DNA binding protein 3
TAGLN transgelin
TEAD3 TEA domain family member 3
TET3 tet methylcytosine dioxygenase 3
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBI transforming growth factor, beta-induced, 68kDa
TIGD6 tigger transposable element derived 6
TLN1 talin 1
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TSC22D4 TSC22 domain family, member 4
TSPAN32 tetraspanin 32
WDR25 WD repeat domain 25
ZC3H12A zinc finger CCCH-type containing 12A
ZFHX3 zinc finger homeobox 3
ZNF155 zinc finger protein 155
ZNF222 zinc finger protein 222
ZNF324 zinc finger protein 324
ZNF749 zinc finger protein 749
ZNF76 zinc finger protein 76