indometacin-2377 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the indometacin-2377 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACVR2B activin A receptor, type IIB
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA2P3 annexin A2 pseudogene 3
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATG10 autophagy related 10
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
C14ORF79 chromosome 14 open reading frame 79
C17ORF59 chromosome 17 open reading frame 59
CAV2 caveolin 2
CCL22 chemokine (C-C motif) ligand 22
CD300C CD300c molecule
CDC25C cell division cycle 25C
CDK3 cyclin-dependent kinase 3
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEP164 centrosomal protein 164kDa
CEP250 centrosomal protein 250kDa
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLEC4A C-type lectin domain family 4, member A
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPN2 carboxypeptidase N, polypeptide 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRMP1 collapsin response mediator protein 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DSC3 desmocollin 3
DTNA dystrobrevin, alpha
DTX4 deltex 4, E3 ubiquitin ligase
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EXOSC2 exosome component 2
FN1 fibronectin 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GAS6 growth arrest-specific 6
GHRH growth hormone releasing hormone
GPRC5C G protein-coupled receptor, class C, group 5, member C
GPX2 glutathione peroxidase 2
GRM1 glutamate receptor, metabotropic 1
HDAC7 histone deacetylase 7
HHLA3 HERV-H LTR-associating 3
HIST1H2AL histone cluster 1, H2al
HUNK hormonally up-regulated Neu-associated kinase
HYAL3 hyaluronoglucosaminidase 3
ICA1 islet cell autoantigen 1, 69kDa
IFNW1 interferon, omega 1
IL22 interleukin 22
KAZN kazrin, periplakin interacting protein
KDM7A lysine (K)-specific demethylase 7A
LIMD2 LIM domain containing 2
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MBP myelin basic protein
MCAM melanoma cell adhesion molecule
MICALL1 MICAL-like 1
MTSS1 metastasis suppressor 1
MYO9B myosin IXB
MYOM1 myomesin 1
NCOA3 nuclear receptor coactivator 3
NEBL nebulette
NOV nephroblastoma overexpressed
NPPA natriuretic peptide A
PARP3 poly (ADP-ribose) polymerase family, member 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDE4A phosphodiesterase 4A, cAMP-specific
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHF7 PHD finger protein 7
PLAC4 placenta-specific 4
PML promyelocytic leukemia
PNPLA4 patatin-like phospholipase domain containing 4
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
RAD51B RAD51 paralog B
RASAL2 RAS protein activator like 2
RUNX1 runt-related transcription factor 1
SIM2 single-minded family bHLH transcription factor 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC35F6 solute carrier family 35, member F6
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLIT2 slit homolog 2 (Drosophila)
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SPDEF SAM pointed domain containing ETS transcription factor
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAC SH3 and cysteine rich domain
TAL1 T-cell acute lymphocytic leukemia 1
TEX40 testis expressed 40
TRIM62 tripartite motif containing 62
TRIP11 thyroid hormone receptor interactor 11
UBOX5 U-box domain containing 5
UPB1 ureidopropionase, beta
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFPL1 zinc finger protein-like 1
ZNF3 zinc finger protein 3
ZNF345 zinc finger protein 345

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ACP6 acid phosphatase 6, lysophosphatidic
ADGRE2 adhesion G protein-coupled receptor E2
AGO4 argonaute RISC catalytic component 4
ANKRD55 ankyrin repeat domain 55
ARHGAP25 Rho GTPase activating protein 25
ATAD3A ATPase family, AAA domain containing 3A
BBS1 Bardet-Biedl syndrome 1
BHLHE41 basic helix-loop-helix family, member e41
C6ORF47 chromosome 6 open reading frame 47
CAPRIN2 caprin family member 2
CCDC15 coiled-coil domain containing 15
CCDC85C coiled-coil domain containing 85C
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD82 CD82 molecule
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CKB creatine kinase, brain
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL2 chemokine (C-X-C motif) ligand 2
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DKK2 dickkopf WNT signaling pathway inhibitor 2
DPY19L2P2 DPY19L2 pseudogene 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EMILIN2 elastin microfibril interfacer 2
EXD3 exonuclease 3'-5' domain containing 3
FAM222B family with sequence similarity 222, member B
FBRS fibrosin
FHL3 four and a half LIM domains 3
GDAP2 ganglioside induced differentiation associated protein 2
GLTP glycolipid transfer protein
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNL1 guanine nucleotide binding protein-like 1
GPATCH3 G patch domain containing 3
GRAMD1B GRAM domain containing 1B
HARS2 histidyl-tRNA synthetase 2, mitochondrial
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IL10RA interleukin 10 receptor, alpha
IL2RG interleukin 2 receptor, gamma
ISG15 ISG15 ubiquitin-like modifier
KCTD20 potassium channel tetramerization domain containing 20
LAX1 lymphocyte transmembrane adaptor 1
LIG4 ligase IV, DNA, ATP-dependent
LIN7A lin-7 homolog A (C. elegans)
LINC00339 long intergenic non-protein coding RNA 339
LRP2 low density lipoprotein receptor-related protein 2
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MBTPS2 membrane-bound transcription factor peptidase, site 2
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MMP9 matrix metallopeptidase 9
MTG1 mitochondrial ribosome-associated GTPase 1
MXD3 MAX dimerization protein 3
NBEAL2 neurobeachin-like 2
NCS1 neuronal calcium sensor 1
NECAB3 N-terminal EF-hand calcium binding protein 3
NIPAL2 NIPA-like domain containing 2
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NPFFR1 neuropeptide FF receptor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NPM3 nucleophosmin/nucleoplasmin 3
NRGN neurogranin (protein kinase C substrate, RC3)
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PADI1 peptidyl arginine deiminase, type I
PDZD7 PDZ domain containing 7
PRR4 proline rich 4 (lacrimal)
PYCRL pyrroline-5-carboxylate reductase-like
RAB8B RAB8B, member RAS oncogene family
SCAMP4 secretory carrier membrane protein 4
SEC31B SEC31 homolog B (S. cerevisiae)
SEPW1 selenoprotein W, 1
SIDT1 SID1 transmembrane family, member 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SREBF1 sterol regulatory element binding transcription factor 1
STX17 syntaxin 17
TCTN2 tectonic family member 2
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TMEM14A transmembrane protein 14A
TRAC T cell receptor alpha constant
TRAPPC6A trafficking protein particle complex 6A
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUBA3C tubulin, alpha 3c
USP6 ubiquitin specific peptidase 6
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae)
XAB2 XPA binding protein 2
YEATS2 YEATS domain containing 2
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF16 zinc finger protein 16
ZNF197 zinc finger protein 197
ZNF222 zinc finger protein 222
ZNF253 zinc finger protein 253
ZNF747 zinc finger protein 747
ZSCAN16 zinc finger and SCAN domain containing 16
ZSCAN26 zinc finger and SCAN domain containing 26
ZW10 zw10 kinetochore protein