indometacin-503 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the indometacin-503 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AR androgen receptor
ASCL1 achaete-scute family bHLH transcription factor 1
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BAD BCL2-associated agonist of cell death
BATF3 basic leucine zipper transcription factor, ATF-like 3
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
C14ORF1 chromosome 14 open reading frame 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASR calcium-sensing receptor
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CBY1 chibby homolog 1 (Drosophila)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHD3 chromodomain helicase DNA binding protein 3
CLEC1B C-type lectin domain family 1, member B
CREB3L1 cAMP responsive element binding protein 3-like 1
CROT carnitine O-octanoyltransferase
CUX1 cut-like homeobox 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCHS1 dachsous cadherin-related 1
DCP1A decapping mRNA 1A
DUS2 dihydrouridine synthase 2
DXO decapping exoribonuclease
EGFL7 EGF-like-domain, multiple 7
ELF2 E74-like factor 2 (ets domain transcription factor)
EPS8L1 EPS8-like 1
FHL3 four and a half LIM domains 3
GCHFR GTP cyclohydrolase I feedback regulator
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPR4 G protein-coupled receptor 4
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSTZ1 glutathione S-transferase zeta 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMX1 H6 family homeobox 1
HOXB5 homeobox B5
HPSE heparanase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL11 interleukin 11
IL13 interleukin 13
IL1RN interleukin 1 receptor antagonist
ING4 inhibitor of growth family, member 4
ISYNA1 inositol-3-phosphate synthase 1
KHNYN KH and NYN domain containing
KHSRP KH-type splicing regulatory protein
KIF16B kinesin family member 16B
KIF2A kinesin heavy chain member 2A
KIFC1 kinesin family member C1
KLK8 kallikrein-related peptidase 8
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LRP12 low density lipoprotein receptor-related protein 12
LTB4R leukotriene B4 receptor
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAST4 microtubule associated serine/threonine kinase family member 4
MBOAT7 membrane bound O-acyltransferase domain containing 7
MVB12B multivesicular body subunit 12B
NADK NAD kinase
NCOR2 nuclear receptor corepressor 2
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NOD1 nucleotide-binding oligomerization domain containing 1
NOS1 nitric oxide synthase 1 (neuronal)
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDE4DIP phosphodiesterase 4D interacting protein
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLK3 polo-like kinase 3
PPP1R7 protein phosphatase 1, regulatory subunit 7
PRDX2 peroxiredoxin 2
PRY PTPN13-like, Y-linked
PSG7 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)
PTN pleiotrophin
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PTPN7 protein tyrosine phosphatase, non-receptor type 7
RAP1GAP RAP1 GTPase activating protein
RGS4 regulator of G-protein signaling 4
RPS2 ribosomal protein S2
RRP1 ribosomal RNA processing 1
SBNO2 strawberry notch homolog 2 (Drosophila)
SEPHS1 selenophosphate synthetase 1
SH2D2A SH2 domain containing 2A
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC35E1 solute carrier family 35, member E1
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
STAT5A signal transducer and activator of transcription 5A
STK25 serine/threonine kinase 25
SYNDIG1 synapse differentiation inducing 1
TICAM1 toll-like receptor adaptor molecule 1
TMEM97 transmembrane protein 97
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TTC3 tetratricopeptide repeat domain 3
UBOX5 U-box domain containing 5
YBX2 Y box binding protein 2
YIPF2 Yip1 domain family, member 2
YY1AP1 YY1 associated protein 1
ZER1 zyg-11 related, cell cycle regulator
ZNF287 zinc finger protein 287

decreased expression

Symbol Name
ADM2 adrenomedullin 2
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALPK1 alpha-kinase 1
B3GAT1 beta-1,3-glucuronyltransferase 1
BHMT betaine--homocysteine S-methyltransferase
C2CD5 C2 calcium-dependent domain containing 5
C4BPA complement component 4 binding protein, alpha
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CCL19 chemokine (C-C motif) ligand 19
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CEND1 cell cycle exit and neuronal differentiation 1
CEP131 centrosomal protein 131kDa
CFAP20 cilia and flagella associated protein 20
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CNOT6 CCR4-NOT transcription complex, subunit 6
CORT cortistatin
CREB5 cAMP responsive element binding protein 5
DAGLA diacylglycerol lipase, alpha
DCBLD2 discoidin, CUB and LCCL domain containing 2
DCLRE1A DNA cross-link repair 1A
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DOC2B double C2-like domains, beta
DRP2 dystrophin related protein 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ELAVL4 ELAV like neuron-specific RNA binding protein 4
FRAS1 Fraser extracellular matrix complex subunit 1
FXYD6 FXYD domain containing ion transport regulator 6
GLI3 GLI family zinc finger 3
GPATCH1 G patch domain containing 1
GPR182 G protein-coupled receptor 182
GUSBP3 glucuronidase, beta pseudogene 3
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HHLA1 HERV-H LTR-associating 1
HPGDS hematopoietic prostaglandin D synthase
IGFALS insulin-like growth factor binding protein, acid labile subunit
INHBC inhibin, beta C
INTS12 integrator complex subunit 12
JAM2 junctional adhesion molecule 2
KIAA1324 KIAA1324
KIF5A kinesin family member 5A
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KRT1 keratin 1, type II
KRT9 keratin 9, type I
LHX6 LIM homeobox 6
LRRC61 leucine rich repeat containing 61
MAGOHB mago-nashi homolog B (Drosophila)
MAPKBP1 mitogen-activated protein kinase binding protein 1
MCHR1 melanin-concentrating hormone receptor 1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MISP mitotic spindle positioning
MST1R macrophage stimulating 1 receptor
MT1H metallothionein 1H
MTERF4 mitochondrial transcription termination factor 4
NDOR1 NADPH dependent diflavin oxidoreductase 1
NPFFR1 neuropeptide FF receptor 1
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PAX1 paired box 1
PCDHB6 protocadherin beta 6
POMT2 protein-O-mannosyltransferase 2
PQLC3 PQ loop repeat containing 3
PRDM14 PR domain containing 14
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
PYGM phosphorylase, glycogen, muscle
RAB3D RAB3D, member RAS oncogene family
RAB8B RAB8B, member RAS oncogene family
RBM41 RNA binding motif protein 41
RRAS related RAS viral (r-ras) oncogene homolog
SH2B2 SH2B adaptor protein 2
SHPK sedoheptulokinase
SLBP stem-loop binding protein
SLC2A4RG SLC2A4 regulator
SLC38A3 solute carrier family 38, member 3
SLPI secretory leukocyte peptidase inhibitor
SPDL1 spindle apparatus coiled-coil protein 1
SPP2 secreted phosphoprotein 2, 24kDa
SPTBN5 spectrin, beta, non-erythrocytic 5
SSBP3 single stranded DNA binding protein 3
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
SURF2 surfeit 2
SUSD6 sushi domain containing 6
SYNGR2 synaptogyrin 2
SYT17 synaptotagmin XVII
SYTL2 synaptotagmin-like 2
TAS2R14 taste receptor, type 2, member 14
TCN2 transcobalamin II
THEG theg spermatid protein
TMEM59L transmembrane protein 59-like
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNR tenascin R
TOE1 target of EGR1, member 1 (nuclear)
TSHZ2 teashirt zinc finger homeobox 2
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1
WT1-AS WT1 antisense RNA
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZCCHC6 zinc finger, CCHC domain containing 6
ZPBP zona pellucida binding protein