indometacin-5049 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the indometacin-5049 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIM2 absent in melanoma 2
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALMS1 Alstrom syndrome protein 1
AMH anti-Mullerian hormone
ANGEL2 angel homolog 2 (Drosophila)
ANGPTL2 angiopoietin-like 2
ARHGAP35 Rho GTPase activating protein 35
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARPIN actin-related protein 2/3 complex inhibitor
BCAM basal cell adhesion molecule (Lutheran blood group)
CA9 carbonic anhydrase IX
CD7 CD7 molecule
CD80 CD80 molecule
CDK10 cyclin-dependent kinase 10
CEP135 centrosomal protein 135kDa
CHGA chromogranin A
CRAT carnitine O-acetyltransferase
DDN dendrin
DOCK10 dedicator of cytokinesis 10
EDDM3A epididymal protein 3A
ERC2-IT1 ERC2 intronic transcript 1
ESRRG estrogen-related receptor gamma
FBXO21 F-box protein 21
FCAR Fc fragment of IgA receptor
FGFR1 fibroblast growth factor receptor 1
FZD1 frizzled class receptor 1
GAL galanin/GMAP prepropeptide
GALR3 galanin receptor 3
GJA9 gap junction protein, alpha 9, 59kDa
GK3P glycerol kinase 3 pseudogene
GYPB glycophorin B (MNS blood group)
HEATR6 HEAT repeat containing 6
HFE hemochromatosis
HLF hepatic leukemia factor
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGFBP5 insulin-like growth factor binding protein 5
IL12RB1 interleukin 12 receptor, beta 1
IRS4 insulin receptor substrate 4
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KALRN kalirin, RhoGEF kinase
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIF25 kinesin family member 25
KIF25-AS1 KIF25 antisense RNA 1
KLHL24 kelch-like family member 24
KLHL25 kelch-like family member 25
LDAH lipid droplet associated hydrolase
LINC00115 long intergenic non-protein coding RNA 115
LINC00260 long intergenic non-protein coding RNA 260
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAPK11 mitogen-activated protein kinase 11
MST1 macrophage stimulating 1
MVB12B multivesicular body subunit 12B
MVD mevalonate (diphospho) decarboxylase
NDRG2 NDRG family member 2
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NEBL nebulette
NEUROD1 neuronal differentiation 1
NEUROG1 neurogenin 1
NRAP nebulin-related anchoring protein
NRG1 neuregulin 1
NT5M 5',3'-nucleotidase, mitochondrial
ORC5 origin recognition complex, subunit 5
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA2 protein disulfide isomerase family A, member 2
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLIN2 perilipin 2
POM121 POM121 transmembrane nucleoporin
POU6F1 POU class 6 homeobox 1
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PSD4 pleckstrin and Sec7 domain containing 4
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAB40A RAB40A, member RAS oncogene family
RGS12 regulator of G-protein signaling 12
RIC3 RIC3 acetylcholine receptor chaperone
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RPL35A ribosomal protein L35a
SFTPA2 surfactant protein A2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SRF serum response factor (c-fos serum response element-binding transcription factor)
STK11 serine/threonine kinase 11
TAOK2 TAO kinase 2
TLR4 toll-like receptor 4
TRIM33 tripartite motif containing 33
TSPAN2 tetraspanin 2
TSSK2 testis-specific serine kinase 2
TTC12 tetratricopeptide repeat domain 12
VN1R1 vomeronasal 1 receptor 1
ZFP2 ZFP2 zinc finger protein
ZNF222 zinc finger protein 222
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABHD4 abhydrolase domain containing 4
ABHD8 abhydrolase domain containing 8
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALS2CL ALS2 C-terminal like
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BEX4 brain expressed, X-linked 4
C11ORF80 chromosome 11 open reading frame 80
CA5B carbonic anhydrase VB, mitochondrial
CCDC176 coiled-coil domain containing 176
CCNA1 cyclin A1
CCP110 centriolar coiled coil protein 110kDa
CENPQ centromere protein Q
CLDN14 claudin 14
CLEC2B C-type lectin domain family 2, member B
CPNE7 copine VII
CSF1R colony stimulating factor 1 receptor
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
EFNA3 ephrin-A3
EHF ets homologous factor
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EPHA4 EPH receptor A4
EPHX2 epoxide hydrolase 2, cytoplasmic
ETAA1 Ewing tumor-associated antigen 1
ETNK2 ethanolamine kinase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FA2H fatty acid 2-hydroxylase
FZD8 frizzled class receptor 8
GALT galactose-1-phosphate uridylyltransferase
GLS2 glutaminase 2 (liver, mitochondrial)
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GTF2I general transcription factor IIi
H2AFJ H2A histone family, member J
HIST1H3C histone cluster 1, H3c
HIST1H4C histone cluster 1, H4c
HLA-J major histocompatibility complex, class I, J (pseudogene)
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HP1BP3 heterochromatin protein 1, binding protein 3
INF2 inverted formin, FH2 and WH2 domain containing
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KIAA0754 KIAA0754
KLHL28 kelch-like family member 28
KRT4 keratin 4, type II
LATS1 large tumor suppressor kinase 1
LMO7 LIM domain 7
MANBA mannosidase, beta A, lysosomal
MAPK12 mitogen-activated protein kinase 12
MBTD1 mbt domain containing 1
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NOD1 nucleotide-binding oligomerization domain containing 1
NOL12 nucleolar protein 12
NUP62CL nucleoporin 62kDa C-terminal like
PARD6A par-6 family cell polarity regulator alpha
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDZD2 PDZ domain containing 2
PHEX phosphate regulating endopeptidase homolog, X-linked
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLK2 polo-like kinase 2
PRR15L proline rich 15-like
PWAR5 Prader Willi/Angelman region RNA 5
RHOBTB2 Rho-related BTB domain containing 2
RPL23AP32 ribosomal protein L23a pseudogene 32
RUNX1-IT1 RUNX1 intronic transcript 1
SCD5 stearoyl-CoA desaturase 5
SCIN scinderin
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SERGEF secretion regulating guanine nucleotide exchange factor
SH2D2A SH2 domain containing 2A
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC35F6 solute carrier family 35, member F6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPEG SPEG complex locus
STRN striatin, calmodulin binding protein
SUGCT succinyl-CoA:glutarate-CoA transferase
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SYTL2 synaptotagmin-like 2
TPST2 tyrosylprotein sulfotransferase 2
TRIM25 tripartite motif containing 25
TSPAN1 tetraspanin 1
USP18 ubiquitin specific peptidase 18
WDR18 WD repeat domain 18
ZBTB44 zinc finger and BTB domain containing 44
ZNF350 zinc finger protein 350
ZNF37BP zinc finger protein 37B, pseudogene
ZNF408 zinc finger protein 408
ZNF552 zinc finger protein 552
ZNF668 zinc finger protein 668