indometacin-5468 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the indometacin-5468 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADGRL1 adhesion G protein-coupled receptor L1
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMACR alpha-methylacyl-CoA racemase
ANGPTL2 angiopoietin-like 2
APC adenomatous polyposis coli
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BTF3P11 basic transcription factor 3 pseudogene 11
C16ORF45 chromosome 16 open reading frame 45
C8A complement component 8, alpha polypeptide
CARD14 caspase recruitment domain family, member 14
CCPG1 cell cycle progression 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CFLAR CASP8 and FADD-like apoptosis regulator
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLPS colipase, pancreatic
CLUL1 clusterin-like 1 (retinal)
CNTD2 cyclin N-terminal domain containing 2
COL14A1 collagen, type XIV, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CPA1 carboxypeptidase A1 (pancreatic)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CYHR1 cysteine/histidine-rich 1
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
ELMO2 engulfment and cell motility 2
ENO3 enolase 3 (beta, muscle)
ERAP1 endoplasmic reticulum aminopeptidase 1
FER fer (fps/fes related) tyrosine kinase
FGF4 fibroblast growth factor 4
FOXN3 forkhead box N3
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLB1L galactosidase, beta 1-like
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GRIP2 glutamate receptor interacting protein 2
HAPLN1 hyaluronan and proteoglycan link protein 1
HDAC9 histone deacetylase 9
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HGD homogentisate 1,2-dioxygenase
HHAT hedgehog acyltransferase
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HP1BP3 heterochromatin protein 1, binding protein 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
INO80B INO80 complex subunit B
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
KDM8 lysine (K)-specific demethylase 8
KLF6 Kruppel-like factor 6
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LIMCH1 LIM and calponin homology domains 1
LINC00597 long intergenic non-protein coding RNA 597
LMF1 lipase maturation factor 1
LRP6 low density lipoprotein receptor-related protein 6
MAPK13 mitogen-activated protein kinase 13
MFAP5 microfibrillar associated protein 5
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MT4 metallothionein 4
MTA1 metastasis associated 1
N4BP3 NEDD4 binding protein 3
NELL2 NEL-like 2 (chicken)
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OMD osteomodulin
PARVB parvin, beta
PENK proenkephalin
PKLR pyruvate kinase, liver and RBC
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PRKCE protein kinase C, epsilon
PVT1 Pvt1 oncogene (non-protein coding)
RAD51 RAD51 recombinase
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RECQL5 RecQ protein-like 5
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPL35A ribosomal protein L35a
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RYR1 ryanodine receptor 1 (skeletal)
SBNO2 strawberry notch homolog 2 (Drosophila)
SC5D sterol-C5-desaturase
SCN10A sodium channel, voltage gated, type X alpha subunit
SIRAL2 SIR2 antiphage like 2
SIX1 SIX homeobox 1
SPEF1 sperm flagellar 1
SPRYD7 SPRY domain containing 7
TFF2 trefoil factor 2
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM212 transmembrane protein 212
TRIO trio Rho guanine nucleotide exchange factor
TSGA10 testis specific, 10
VEGFA vascular endothelial growth factor A
WSCD1 WSC domain containing 1
ZNF286A zinc finger protein 286A
ZNF324 zinc finger protein 324

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ACYP2 acylphosphatase 2, muscle type
ADTRP androgen-dependent TFPI-regulating protein
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ARFRP1 ADP-ribosylation factor related protein 1
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BAHD1 bromo adjacent homology domain containing 1
BPGM 2,3-bisphosphoglycerate mutase
CALCOCO1 calcium binding and coiled-coil domain 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC170 coiled-coil domain containing 170
CCDC94 coiled-coil domain containing 94
CCNJ cyclin J
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK20 cyclin-dependent kinase 20
CENPO centromere protein O
CEP72 centrosomal protein 72kDa
CEP97 centrosomal protein 97kDa
CHML choroideremia-like (Rab escort protein 2)
COL9A2 collagen, type IX, alpha 2
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DSCAM Down syndrome cell adhesion molecule
DUSP2 dual specificity phosphatase 2
ERI3 ERI1 exoribonuclease family member 3
ERN2 endoplasmic reticulum to nucleus signaling 2
EXOC5 exocyst complex component 5
F2R coagulation factor II (thrombin) receptor
FBRS fibrosin
FBXO31 F-box protein 31
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FMO4 flavin containing monooxygenase 4
GID4 GID complex subunit 4
GLI3 GLI family zinc finger 3
H2AFY2 H2A histone family, member Y2
HOXC10 homeobox C10
IL17RA interleukin 17 receptor A
IL2 interleukin 2
IMPACT impact RWD domain protein
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
KCNK15 potassium channel, two pore domain subfamily K, member 15
KREMEN2 kringle containing transmembrane protein 2
LOC100286895 cell division cycle 27 homolog pseudogene
LOC390998 ribosomal protein L10 pseudogene
LRP5L low density lipoprotein receptor-related protein 5-like
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MRPL41 mitochondrial ribosomal protein L41
MTCL1 microtubule crosslinking factor 1
MTERF4 mitochondrial transcription termination factor 4
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NIPAL2 NIPA-like domain containing 2
PELI1 pellino E3 ubiquitin protein ligase 1
PGPEP1 pyroglutamyl-peptidase I
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PROCR protein C receptor, endothelial
PTDSS2 phosphatidylserine synthase 2
PTPN9 protein tyrosine phosphatase, non-receptor type 9
RANGRF RAN guanine nucleotide release factor
RASA2 RAS p21 protein activator 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFTN1 raftlin, lipid raft linker 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF25 ring finger protein 25
RPAP2 RNA polymerase II associated protein 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RWDD3 RWD domain containing 3
SAMHD1 SAM domain and HD domain 1
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SOX3 SRY (sex determining region Y)-box 3
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SUOX sulfite oxidase
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM53 transmembrane protein 53
TRABD TraB domain containing
TRAIP TRAF interacting protein
TRIM36 tripartite motif containing 36
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC33 tetratricopeptide repeat domain 33
TUBA3C tubulin, alpha 3c
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
XAB2 XPA binding protein 2
YEATS2 YEATS domain containing 2
ZNF212 zinc finger protein 212
ZNF250 zinc finger protein 250
ZNF668 zinc finger protein 668
ZNF747 zinc finger protein 747