induced chromosome breakage Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description chromosome breakage following treatment with a DNA-damaging agent (Mammalian Phenotype Ontology, MP_0004030)
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19 gene mutations causing the induced chromosome breakage phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ATR ATR serine/threonine kinase
DCLRE1C DNA cross-link repair 1C
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FANCG Fanconi anemia, complementation group G
HUS1 HUS1 checkpoint homolog (S. pombe)
LIG4 ligase IV, DNA, ATP-dependent
MCM4 minichromosome maintenance complex component 4
MCPH1 microcephalin 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
SLX4 SLX4 structure-specific endonuclease subunit
TP53BP1 tumor protein p53 binding protein 1
TYR tyrosinase
USP1 ubiquitin specific peptidase 1