infertility Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility. (Experimental Factor Ontology, EFO_0000545)
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Genes

721 genes co-occuring with the disease infertility in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.65816
AMH anti-Mullerian hormone 1.9797
FSHR follicle stimulating hormone receptor 1.96989
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 1.84909
ACR acrosin 1.78308
PRL prolactin 1.75913
BMP15 bone morphogenetic protein 15 1.7396
GDF9 growth differentiation factor 9 1.73778
DAZL deleted in azoospermia-like 1.72958
PRM1 protamine 1 1.72
PRM2 protamine 2 1.62291
SHBG sex hormone-binding globulin 1.60323
DAZ1 deleted in azoospermia 1 1.57957
PAEP progestagen-associated endometrial protein 1.57913
DAZ2 deleted in azoospermia 2 1.57556
SRY sex determining region Y 1.49789
HOXA10 homeobox A10 1.49789
AR androgen receptor 1.4913
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 1.48252
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 1.48121
LEP leptin 1.46583
INS insulin 1.42498
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.4184
STRA8 stimulated by retinoic acid 8 1.38603
INSL3 insulin-like 3 (Leydig cell) 1.36727
ZP4 zona pellucida glycoprotein 4 1.35943
LHCGR luteinizing hormone/choriogonadotropin receptor 1.35681
CD79A CD79a molecule, immunoglobulin-associated alpha 1.34417
USP26 ubiquitin specific peptidase 26 1.33763
ESR1 estrogen receptor 1 1.32017
TNP2 transition protein 2 (during histone to protamine replacement) 1.31493
CATSPER2 cation channel, sperm associated 2 1.2861
ADAM2 ADAM metallopeptidase domain 2 1.28173
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 1.25907
STAR steroidogenic acute regulatory protein 1.23169
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 1.21868
FIGLA folliculogenesis specific basic helix-loop-helix 1.21825
FSHB follicle stimulating hormone, beta polypeptide 1.21695
KDM6A lysine (K)-specific demethylase 6A 1.20915
TNP1 transition protein 1 (during histone to protamine replacement) 1.20396
CATSPER1 cation channel, sperm associated 1 1.2031
TEX12 testis expressed 12 1.19964
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.19229
FOXL2 forkhead box L2 1.18324
TSSK2 testis-specific serine kinase 2 1.17507
PGR progesterone receptor 1.15837
LEPR leptin receptor 1.15752
SPEF2 sperm flagellar 2 1.15666
RHCG Rh family, C glycoprotein 1.15368
SYCP3 synaptonemal complex protein 3 1.13585
KISS1R KISS1 receptor 1.13501
TCHH trichohyalin 1.12952
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 1.11099
MSH6 mutS homolog 6 1.10048
POMC proopiomelanocortin 1.09167
ESR2 estrogen receptor 2 (ER beta) 1.07614
NOBOX NOBOX oogenesis homeobox 1.07152
MOV10L1 Mov10 RISC complex RNA helicase like 1 1.07068
DPY19L2 dpy-19-like 2 (C. elegans) 1.06774
IGFBP1 insulin-like growth factor binding protein 1 1.06732
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 1.06354
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 1.06102
DNTT DNA nucleotidylexotransferase 1.05429
IGF1 insulin-like growth factor 1 (somatomedin C) 1.04966
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.0484
GNRHR gonadotropin-releasing hormone receptor 1.03198
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 1.02988
HSPA2 heat shock 70kDa protein 2 1.01512
CDY1 chromodomain protein, Y-linked, 1 1.01005
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 1.00879
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.994017
SOD2 superoxide dismutase 2, mitochondrial 0.988535
SGOL2 shugoshin-like 2 (S. pombe) 0.985585
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2 0.983479
TRH thyrotropin-releasing hormone 0.982636
UNK unkempt family zinc finger 0.980952
NANOS2 nanos homolog 2 (Drosophila) 0.978848
CDY1B chromodomain protein, Y-linked, 1B 0.974221
FMR1 fragile X mental retardation 1 0.967502
IZUMO1 izumo sperm-egg fusion 1 0.958705
CREM cAMP responsive element modulator 0.957868
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 0.957033
PLCZ1 phospholipase C, zeta 1 0.938289
CRISP2 cysteine-rich secretory protein 2 0.937044
NANOS1 nanos homolog 1 (Drosophila) 0.932484
PGAM4 phosphoglycerate mutase family member 4 0.93207
OR1D2 olfactory receptor, family 1, subfamily D, member 2 0.930828
NANOS3 nanos homolog 3 (Drosophila) 0.925452
SPAG9 sperm associated antigen 9 0.923387
SPATA22 spermatogenesis associated 22 0.920498
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.920085
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.915139
AKAP4 A kinase (PRKA) anchor protein 4 0.910199
AMHR2 anti-Mullerian hormone receptor, type II 0.909787
LHB luteinizing hormone beta polypeptide 0.906909
GPX4 glutathione peroxidase 4 0.89541
USP9Y ubiquitin specific peptidase 9, Y-linked 0.894589
TNF tumor necrosis factor 0.893359
EPPIN epididymal peptidase inhibitor 0.892129
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.886799
GPX5 glutathione peroxidase 5 0.88393
NPY neuropeptide Y 0.874919
MSH4 mutS homolog 4 0.871234
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.866321
TCP11 t-complex 11, testis-specific 0.866321
ODF1 outer dense fiber of sperm tails 1 0.866321
GTF2A1L general transcription factor IIA, 1-like 0.857315
HOXA11 homeobox A11 0.856905
PRLR prolactin receptor 0.856497
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.851583
TUBA3C tubulin, alpha 3c 0.851173
RXFP2 relaxin/insulin-like family peptide receptor 2 0.844621
TPO thyroid peroxidase 0.843392
VCL vinculin 0.841753
GPX1 glutathione peroxidase 1 0.840115
INHA inhibin, alpha 0.839296
AURKC aurora kinase C 0.835198
SPATA16 spermatogenesis associated 16 0.823718
IZUMO2 IZUMO family member 2 0.818796
TSSK1B testis-specific serine kinase 1B 0.818796
OOSP1 oocyte secreted protein 1, pseudogene 0.818796
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E 0.818796
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 0.818796
RNF187 ring finger protein 187 0.818796
SPATA33 spermatogenesis associated 33 0.818796
AK8 adenylate kinase 8 0.818796
TBPL2 TATA box binding protein like 2 0.818796
KCNU1 potassium channel, subfamily U, member 1 0.811821
IQCG IQ motif containing G 0.80977
OVGP1 oviductal glycoprotein 1, 120kDa 0.806898
ZFP36L2 ZFP36 ring finger protein-like 2 0.805257
LHX8 LIM homeobox 8 0.804436
GGN gametogenetin 0.803205
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.799513
RAB14 RAB14, member RAS oncogene family 0.792951
SPO11 SPO11 meiotic protein covalently bound to DSB 0.787623
KATNAL1 katanin p60 subunit A-like 1 0.786394
ALB albumin 0.786394
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.785165
TSKS testis-specific serine kinase substrate 0.783116
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 0.782298
LDHC lactate dehydrogenase C 0.779023
HSPE1 heat shock 10kDa protein 1 0.770027
PROX2 prospero homeobox 2 0.767985
MIF4GD MIF4G domain containing 0.767985
AGO2 argonaute RISC catalytic component 2 0.766759
NXF2 nuclear RNA export factor 2 0.765535
NXF2B nuclear RNA export factor 2B 0.765535
LNPEP leucyl/cystinyl aminopeptidase 0.764718
PZP pregnancy-zone protein 0.762271
STRC stereocilin 0.759824
STRCP1 stereocilin pseudogene 1 0.759824
SYCP1 synaptonemal complex protein 1 0.759416
UQCRC2 ubiquinol-cytochrome c reductase core protein II 0.755749
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 0.743141
IL6 interleukin 6 0.740299
IL1B interleukin 1, beta 0.739082
SNRPN small nuclear ribonucleoprotein polypeptide N 0.732596
FST follistatin 0.728547
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.728143
POTEB POTE ankyrin domain family, member B 0.727333
WBP2NL WBP2 N-terminal like 0.727333
POTED POTE ankyrin domain family, member D 0.727333
MIR3118-1 microRNA 3118-1 0.727333
CD9 CD9 molecule 0.724907
STPG2 sperm-tail PG-rich repeat containing 2 0.720461
PRSS55 protease, serine, 55 0.720058
TMPRSS12 transmembrane (C-terminal) protease, serine 12 0.720058
KISS1 KiSS-1 metastasis-suppressor 0.709572
NCAM1 neural cell adhesion molecule 1 0.706351
TEX11 testis expressed 11 0.705144
ANXA5 annexin A5 0.703134
PIWIL2 piwi-like RNA-mediated gene silencing 2 0.695103
H1FOO H1 histone family, member O, oocyte-specific 0.693098
IFI30 interferon, gamma-inducible protein 30 0.687091
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.684692
PRAMEF6 PRAME family member 6 0.683493
OR2W3 olfactory receptor, family 2, subfamily W, member 3 0.682693
KLHL10 kelch-like family member 10 0.681495
UBE2B ubiquitin-conjugating enzyme E2B 0.678701
SYCE1 synaptonemal complex central element protein 1 0.671527
CAT catalase 0.664372
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 0.66199
ARMC4 armadillo repeat containing 4 0.656837
DMRT1 doublesex and mab-3 related transcription factor 1 0.656837
DEFB126 defensin, beta 126 0.655254
RBMY1A1 RNA binding motif protein, Y-linked, family 1, member A1 0.655254
POLG polymerase (DNA directed), gamma 0.649323
SMC1B structural maintenance of chromosomes 1B 0.648138
NLRP5 NLR family, pyrin domain containing 5 0.64577
IL11 interleukin 11 0.642615
AMER1 APC membrane recruitment protein 1 0.63907
TEKT4 tektin 4 0.635921
AGRP agouti related neuropeptide 0.633956
SHOX short stature homeobox 0.633563
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.633169
ACRV1 acrosomal vesicle protein 1 0.633169
H1FNT H1 histone family, member N, testis-specific 0.630027
PHGDH phosphoglycerate dehydrogenase 0.623751
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.621792
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.6214
TSNAX translin-associated factor X 0.615529
GATA6 GATA binding protein 6 0.614747
FOXP2 forkhead box P2 0.613183
CXCL8 chemokine (C-X-C motif) ligand 8 0.609666
TGFB1 transforming growth factor, beta 1 0.609276
C19ORF26 chromosome 19 open reading frame 26 0.606543
PGF placental growth factor 0.606152
DMC1 DNA meiotic recombinase 1 0.605762
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 0.605372
HSFY1 heat shock transcription factor, Y-linked 1 0.604201
HSFY2 heat shock transcription factor, Y linked 2 0.604201
MCM8 minichromosome maintenance complex component 8 0.595623
TUBA3D tubulin, alpha 3d 0.594454
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 0.594454
PSG2 pregnancy specific beta-1-glycoprotein 2 0.586665
ACPP acid phosphatase, prostate 0.585497
FN1 fibronectin 1 0.585497
KL klotho 0.583552
NSUN7 NOP2/Sun domain family, member 7 0.583552
TPST2 tyrosylprotein sulfotransferase 2 0.582384
STAG3 stromal antigen 3 0.578494
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.578494
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.575772
HLA-C major histocompatibility complex, class I, C 0.574217
TAC3 tachykinin 3 0.574217
SOX8 SRY (sex determining region Y)-box 8 0.57305
CLGN calmegin 0.568386
GDNF glial cell derived neurotrophic factor 0.566443
HOXA13 homeobox A13 0.560227
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 0.558674
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.55712
KITLG KIT ligand 0.556732
TF transferrin 0.55518
OAZ3 ornithine decarboxylase antizyme 3 0.552851
EGR4 early growth response 4 0.552851
SPAG1 sperm associated antigen 1 0.548971
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit 0.547032
SMAD5 SMAD family member 5 0.54393
LHX3 LIM homeobox 3 0.543542
FAAH fatty acid amide hydrolase 0.541217
CD4 CD4 molecule 0.541217
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.539667
HBEGF heparin-binding EGF-like growth factor 0.538893
PRDM9 PR domain containing 9 0.538118
SPA17 sperm autoantigenic protein 17 0.537344
TES testin LIM domain protein 0.535796
DICER1 dicer 1, ribonuclease type III 0.535796
IGFBP3 insulin-like growth factor binding protein 3 0.532701
FYTTD1 forty-two-three domain containing 1 0.532314
TDRD5 tudor domain containing 5 0.532314
RXFP4 relaxin/insulin-like family peptide receptor 4 0.532314
OCLN occludin 0.529608
ALPPL2 alkaline phosphatase, placental-like 2 0.528449
CSN1S1 casein alpha s1 0.528063
ALPP alkaline phosphatase, placental 0.52729
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.526904
ALPL alkaline phosphatase, liver/bone/kidney 0.526904
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.524588
SCARB1 scavenger receptor class B, member 1 0.523045
DNAAF5 dynein, axonemal, assembly factor 5 0.522273
PEG3 paternally expressed 3 0.521502
CHDH choline dehydrogenase 0.521117
TPST1 tyrosylprotein sulfotransferase 1 0.519575
PIWIL4 piwi-like RNA-mediated gene silencing 4 0.517649
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.514956
PSG1 pregnancy specific beta-1-glycoprotein 1 0.514186
TLR4 toll-like receptor 4 0.513417
POU5F1B POU class 5 homeobox 1B 0.512648
DRAM2 DNA-damage regulated autophagy modulator 2 0.511496
UBB ubiquitin B 0.508424
SPAG16 sperm associated antigen 16 0.507273
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 0.507273
IRS2 insulin receptor substrate 2 0.506123
LBX2 ladybird homeobox 2 0.505356
FASLG Fas ligand (TNF superfamily, member 6) 0.502675
SP6 Sp6 transcription factor 0.499997
YBX2 Y box binding protein 2 0.499997
RXFP1 relaxin/insulin-like family peptide receptor 1 0.498467
NPS neuropeptide S 0.494648
RXFP3 relaxin/insulin-like family peptide receptor 3 0.491978
SYCE2 synaptonemal complex central element protein 2 0.489311
CAPZA3 capping protein (actin filament) muscle Z-line, alpha 3 0.489311
INSR insulin receptor 0.489311
LIPE lipase, hormone-sensitive 0.485125
GPR12 G protein-coupled receptor 12 0.483224
OR2T33 olfactory receptor, family 2, subfamily T, member 33 0.480945
PTGES prostaglandin E synthase 0.480566
ZFY zinc finger protein, Y-linked 0.479427
GSTM1 glutathione S-transferase mu 1 0.478289
GJA1 gap junction protein, alpha 1, 43kDa 0.477909
BAX BCL2-associated X protein 0.477909
TDRD9 tudor domain containing 9 0.476772
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.475255
FOXO1 forkhead box O1 0.472604
PLG plasminogen 0.472604
FOXO3 forkhead box O3 0.471468
WNT7A wingless-type MMTV integration site family, member 7A 0.471468
TP53 tumor protein p53 0.467684
NANOG Nanog homeobox 0.467684
AHR aryl hydrocarbon receptor 0.467306
DND1 DND microRNA-mediated repression inhibitor 1 0.465794
VEGFA vascular endothelial growth factor A 0.465416
BRCA2 breast cancer 2, early onset 0.465038
F5 coagulation factor V (proaccelerin, labile factor) 0.465038
SPACA3 sperm acrosome associated 3 0.463527
DMRT3 doublesex and mab-3 related transcription factor 3 0.463149
WDR20 WD repeat domain 20 0.462394
SPATA1 spermatogenesis associated 1 0.458996
GSTA1 glutathione S-transferase alpha 1 0.458619
RHOXF2 Rhox homeobox family, member 2 0.458241
TTLL5 tubulin tyrosine ligase-like family member 5 0.456732
AKAP3 A kinase (PRKA) anchor protein 3 0.455224
PCSK4 proprotein convertase subtilisin/kexin type 4 0.453716
CCL2 chemokine (C-C motif) ligand 2 0.453716
UBAP2L ubiquitin associated protein 2-like 0.452585
TRIM61 tripartite motif containing 61 0.451831
CXXC5 CXXC finger protein 5 0.450324
SLC22A23 solute carrier family 22, member 23 0.448441
SOX9 SRY (sex determining region Y)-box 9 0.448064
PICK1 protein interacting with PRKCA 1 0.447687
SAFB scaffold attachment factor B 0.447311
SOX3 SRY (sex determining region Y)-box 3 0.446935
GHRL ghrelin/obestatin prepropeptide 0.446182
TLR1 toll-like receptor 1 0.446182
CDC26 cell division cycle 26 0.443923
PGRMC2 progesterone receptor membrane component 2 0.443547
PROKR2 prokineticin receptor 2 0.443547
STARD4 StAR-related lipid transfer (START) domain containing 4 0.442795
EFCAB6 EF-hand calcium binding domain 6 0.442795
ASTL astacin-like metallo-endopeptidase (M12 family) 0.442795
NRIP1 nuclear receptor interacting protein 1 0.440914
DNAH9 dynein, axonemal, heavy chain 9 0.440162
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 0.440162
GSTA3 glutathione S-transferase alpha 3 0.439786
GSTA2 glutathione S-transferase alpha 2 0.438282
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 0.437906
GSTA4 glutathione S-transferase alpha 4 0.437154
OR6C2 olfactory receptor, family 6, subfamily C, member 2 0.436778
ITGA6 integrin, alpha 6 0.434899
MEI1 meiosis inhibitor 1 0.434524
PYGO2 pygopus family PHD finger 2 0.433772
FCRL3 Fc receptor-like 3 0.431519
HSPA4 heat shock 70kDa protein 4 0.431144
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 0.42589
DNAI2 dynein, axonemal, intermediate chain 2 0.425139
POU5F1 POU class 5 homeobox 1 0.424014
KATNB1 katanin p80 (WD repeat containing) subunit B 1 0.42214
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.421016
DCC DCC netrin 1 receptor 0.420641
DAZ3 deleted in azoospermia 3 0.420641
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.419517
GBP2 guanylate binding protein 2, interferon-inducible 0.419517
ANXA13 annexin A13 0.419142
PDIA3 protein disulfide isomerase family A, member 3 0.418768
IGF2 insulin-like growth factor 2 0.418768
CD52 CD52 molecule 0.416896
RBM43 RNA binding motif protein 43 0.416896
PDLIM2 PDZ and LIM domain 2 (mystique) 0.415773
BRCA1 breast cancer 1, early onset 0.41465
RLN3 relaxin 3 0.414276
UBE2H ubiquitin-conjugating enzyme E2H 0.412779
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 0.412779
GGNBP1 gametogenetin binding protein 1 (pseudogene) 0.412779
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.410535
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.410535
TEX14 testis expressed 14 0.409414
ZGLP1 zinc finger, GATA-like protein 1 0.409414
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.405305
ACTB actin, beta 0.405305
MSMB microseminoprotein, beta- 0.404184
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 0.403438
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.403064
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.402318
GDF6 growth differentiation factor 6 0.400826
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.396725
CCDC114 coiled-coil domain containing 114 0.39598
PUM2 pumilio RNA-binding family member 2 0.394491
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.393374
F2 coagulation factor II (thrombin) 0.393001
TG thyroglobulin 0.393001
LIFR leukemia inhibitory factor receptor alpha 0.392257
ETV5 ets variant 5 0.389281
GFRA1 GDNF family receptor alpha 1 0.389281
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase 0.387423
AQP9 aquaporin 9 0.387051
ADCY2 adenylate cyclase 2 (brain) 0.386679
RBMXL2 RNA binding motif protein, X-linked-like 2 0.385193
BCL2L10 BCL2-like 10 (apoptosis facilitator) 0.384451
CLOCK clock circadian regulator 0.38111
ZNF778 zinc finger protein 778 0.380368
FKBP4 FK506 binding protein 4, 59kDa 0.379997
RHOXF1 Rhox homeobox family, member 1 0.377773
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.377031
FBXO21 F-box protein 21 0.376661
ADAM7 ADAM metallopeptidase domain 7 0.376661
ACTG1 actin gamma 1 0.37555
CLDN11 claudin 11 0.374809
CPE carboxypeptidase E 0.374068
FLNA filamin A, alpha 0.374068
SPAG11B sperm associated antigen 11B 0.372587
MNX1 motor neuron and pancreas homeobox 1 0.371107
BRDT bromodomain, testis-specific 0.370368
NPR2 natriuretic peptide receptor 2 0.369628
CBX1 chromobox homolog 1 0.368888
BRSK2 BR serine/threonine kinase 2 0.368888
UBC ubiquitin C 0.368518
ACTL7A actin-like 7A 0.368149
RABL2A RAB, member of RAS oncogene family-like 2A 0.36741
RABL2B RAB, member of RAS oncogene family-like 2B 0.36741
RAD51 RAD51 recombinase 0.36704
HIST1H1T histone cluster 1, H1t 0.366671
GOPC golgi-associated PDZ and coiled-coil motif containing 0.365193
ATM ATM serine/threonine kinase 0.363716
DSCAML1 Down syndrome cell adhesion molecule like 1 0.361133
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.360026
RPS27A ribosomal protein S27a 0.359657
TSSK6 testis-specific serine kinase 6 0.358551
SPP1 secreted phosphoprotein 1 0.357446
OLA1 Obg-like ATPase 1 0.357077
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.356341
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 0.356341
LTF lactotransferrin 0.355604
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.352291
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 0.350452
STXBP5L syntaxin binding protein 5-like 0.350452
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.350452
TPPP2 tubulin polymerization-promoting protein family member 2 0.350084
RACGAP1 Rac GTPase activating protein 1 0.350084
FTHL17 ferritin, heavy polypeptide-like 17 0.349717
RNF144B ring finger protein 144B 0.349717
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.347879
PRDX1 peroxiredoxin 1 0.347144
TGFB2 transforming growth factor, beta 2 0.346777
SPAG8 sperm associated antigen 8 0.345675
DKKL1 dickkopf-like 1 0.344574
SYNE2 spectrin repeat containing, nuclear envelope 2 0.344207
MLN motilin 0.34384
TEKT1 tektin 1 0.343473
GLYCAM1 glycosylation dependent cell adhesion molecule 1 (pseudogene) 0.342006
IL10 interleukin 10 0.337242
DCXR dicarbonyl/L-xylulose reductase 0.334681
CD46 CD46 molecule, complement regulatory protein 0.332852
DPF3 D4, zinc and double PHD fingers, family 3 0.332487
SPIN1 spindlin 1 0.33066
PRM3 protamine 3 0.32993
SEPHS2 selenophosphate synthetase 2 0.32993
SFRP4 secreted frizzled-related protein 4 0.32993
SNRPF small nuclear ribonucleoprotein polypeptide F 0.328834
ZNF215 zinc finger protein 215 0.328834
NOS3 nitric oxide synthase 3 (endothelial cell) 0.328105
HSFX1 heat shock transcription factor family, X linked 1 0.328105
HSFX2 heat shock transcription factor family, X linked 2 0.328105
DNAH1 dynein, axonemal, heavy chain 1 0.325916
TACR3 tachykinin receptor 3 0.324823
CLDN12 claudin 12 0.324823
PIWIL3 piwi-like RNA-mediated gene silencing 3 0.32373
TJP1 tight junction protein 1 0.323002
C3 complement component 3 0.321181
IGF2R insulin-like growth factor 2 receptor 0.320454
GTSF1 gametocyte specific factor 1 0.317909
AGFG1 ArfGAP with FG repeats 1 0.317545
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.316819
HAS2 hyaluronan synthase 2 0.315366
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.314278
MMP2 matrix metallopeptidase 2 0.313915
SLPI secretory leukocyte peptidase inhibitor 0.313552
HIST2H2AC histone cluster 2, H2ac 0.313189
HIST2H2AA3 histone cluster 2, H2aa3 0.312827
HIST2H2AA4 histone cluster 2, H2aa4 0.312827
CCNA1 cyclin A1 0.312464
IFT20 intraflagellar transport 20 0.311377
TSPYL1 TSPY-like 1 0.309566
KLK3 kallikrein-related peptidase 3 0.308842
PPARG peroxisome proliferator-activated receptor gamma 0.30848
KLF9 Kruppel-like factor 9 0.30848
GSTT1 glutathione S-transferase theta 1 0.30848
GSTTP1 glutathione S-transferase theta pseudogene 1 0.30848
FMN2 formin 2 0.307033
FGF2 fibroblast growth factor 2 (basic) 0.30631
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.305226
AKAP11 A kinase (PRKA) anchor protein 11 0.300173
ZMIZ1 zinc finger, MIZ-type containing 1 0.300173
AMBP alpha-1-microglobulin/bikunin precursor 0.299092
FOXP3 forkhead box P3 0.299092
GSR glutathione reductase 0.299092
GALT galactose-1-phosphate uridylyltransferase 0.298731
TEX15 testis expressed 15 0.297291
FGF4 fibroblast growth factor 4 0.296571
GAN gigaxonin 0.296571
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 0.295492
ANOS1 anosmin 1 0.294413
IL1R2 interleukin 1 receptor, type II 0.292975
PCNA proliferating cell nuclear antigen 0.292616
TAS1R3 taste receptor, type 1, member 3 0.291898
CFD complement factor D (adipsin) 0.291539
TUBA4A tubulin, alpha 4a 0.289744
SPAG17 sperm associated antigen 17 0.289386
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.289386
CETN1 centrin, EF-hand protein, 1 0.289027
PTEN phosphatase and tensin homolog 0.285802
MMP9 matrix metallopeptidase 9 0.285444
TGFB3 transforming growth factor, beta 3 0.285086
MC4R melanocortin 4 receptor 0.285086
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 0.281868
PROS1 protein S (alpha) 0.28151
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 0.280082
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.277584
IFNG interferon, gamma 0.277227
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.27687
RSPH9 radial spoke head 9 homolog (Chlamydomonas) 0.27687
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 0.276514
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.276158
RPL21 ribosomal protein L21 0.275801
FOS FBJ murine osteosarcoma viral oncogene homolog 0.275445
BOLL boule-like RNA-binding protein 0.274376
SEPT12 septin 12 0.274376
BMP4 bone morphogenetic protein 4 0.273664
DMXL2 Dmx-like 2 0.273308
PTTG1 pituitary tumor-transforming 1 0.272953
MAEL maelstrom spermatogenic transposon silencer 0.272597
MCEE methylmalonyl CoA epimerase 0.270464
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.270108
PTGER3 prostaglandin E receptor 3 (subtype EP3) 0.269398
VDAC2 voltage-dependent anion channel 2 0.268332
TUBA8 tubulin, alpha 8 0.267977
TLR5 toll-like receptor 5 0.267622
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.266558
AHSG alpha-2-HS-glycoprotein 0.26514
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.263722
MLXIPL MLX interacting protein-like 0.263722
SH2B1 SH2B adaptor protein 1 0.263368
SOX2 SRY (sex determining region Y)-box 2 0.263368
CRH corticotropin releasing hormone 0.263014
INMT indolethylamine N-methyltransferase 0.26266
NTF4 neurotrophin 4 0.261599
MAPK14 mitogen-activated protein kinase 14 0.261599
ADGRA3 adhesion G protein-coupled receptor A3 0.260891
RETN resistin 0.260891
OSBP2 oxysterol binding protein 2 0.25983
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.259124
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.257358
AMELY amelogenin, Y-linked 0.257358
KRT75 keratin 75, type II 0.255946
BMPR1B bone morphogenetic protein receptor, type IB 0.255594
TLR2 toll-like receptor 2 0.254536
ANAPC4 anaphase promoting complex subunit 4 0.254183
MSH5 mutS homolog 5 0.253831
CSF1 colony stimulating factor 1 (macrophage) 0.253479
AKT1S1 AKT1 substrate 1 (proline-rich) 0.253127
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 0.252422
PKNOX2 PBX/knotted 1 homeobox 2 0.252422
CD68 CD68 molecule 0.250311
ELANE elastase, neutrophil expressed 0.24996
MRPS22 mitochondrial ribosomal protein S22 0.249608
CDK1 cyclin-dependent kinase 1 0.248203
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.247501
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.245747
TRO trophinin 0.245396
GAL galanin/GMAP prepropeptide 0.244345
RPS28 ribosomal protein S28 0.242595
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 0.242245
WASF2 WAS protein family, member 2 0.241895
BMP8B bone morphogenetic protein 8b 0.241196
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.241196
TERT telomerase reverse transcriptase 0.240148
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.238752
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.238054
FGF9 fibroblast growth factor 9 0.237357
DPPA4 developmental pluripotency associated 4 0.237009
DNAH8 dynein, axonemal, heavy chain 8 0.233878
UBA1 ubiquitin-like modifier activating enzyme 1 0.233878
NOTCH1 notch 1 0.232489
IHH indian hedgehog 0.232489
MUC1 mucin 1, cell surface associated 0.231795
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.231448
PIP prolactin-induced protein 0.231102
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.231102
ZBTB16 zinc finger and BTB domain containing 16 0.22937
NHLH2 nescient helix loop helix 2 0.22937
AMELX amelogenin, X-linked 0.228333
CRHR2 corticotropin releasing hormone receptor 2 0.226952
FGFR1 fibroblast growth factor receptor 1 0.226952
TROAP trophinin associated protein 0.226607
MGAM maltase-glucoamylase 0.226607
VRK1 vaccinia related kinase 1 0.225917
GJA4 gap junction protein, alpha 4, 37kDa 0.225573
GGNBP2 gametogenetin binding protein 2 0.225229
MDM4 MDM4, p53 regulator 0.22454
TSC22D3 TSC22 domain family, member 3 0.224196
CCDC40 coiled-coil domain containing 40 0.224196
EPSTI1 epithelial stromal interaction 1 (breast) 0.224196
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.222822
PSME4 proteasome (prosome, macropain) activator subunit 4 0.222479
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.222479
SLC39A5 solute carrier family 39 (zinc transporter), member 5 0.222136
PON1 paraoxonase 1 0.22145
PRSS21 protease, serine, 21 (testisin) 0.220766
NR2C1 nuclear receptor subfamily 2, group C, member 1 0.220766
IL1A interleukin 1, alpha 0.220766
CALCRL calcitonin receptor-like 0.219057
PRND prion protein 2 (dublet) 0.218715
MN1 meningioma (disrupted in balanced translocation) 1 0.218374
SMCP sperm mitochondria-associated cysteine-rich protein 0.218034
POR P450 (cytochrome) oxidoreductase 0.217693
HEMGN hemogen 0.217693
DPPA2 developmental pluripotency associated 2 0.217352
EMX2 empty spiracles homeobox 2 0.217012
TRPC3 transient receptor potential cation channel, subfamily C, member 3 0.215653
PLAT plasminogen activator, tissue 0.214975
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.214636
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.214297
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 0.214297
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 0.213959
LIF leukemia inhibitory factor 0.213621
HNF1B HNF1 homeobox B 0.213283
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 0.211934
PRKY protein kinase, Y-linked, pseudogene 0.211597
ECI1 enoyl-CoA delta isomerase 1 0.211597
MT1A metallothionein 1A 0.211261
CAPZB capping protein (actin filament) muscle Z-line, beta 0.210925
PROK2 prokineticin 2 0.210589
CYTIP cytohesin 1 interacting protein 0.210589
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.209918
KRT18 keratin 18, type I 0.209918
CARD17 caspase recruitment domain family, member 17 0.208914
MT-ATP8 ATP synthase F0 subunit 8 0.208914
IL11RA interleukin 11 receptor, alpha 0.208579
MPO myeloperoxidase 0.208579
MRC1 mannose receptor, C type 1 0.207578
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.20658
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.20658
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.206248
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.205916
TSPO translocator protein (18kDa) 0.205254
DENND1A DENN/MADD domain containing 1A 0.204923
GOLGA3 golgin A3 0.204923
ODF2 outer dense fiber of sperm tails 2 0.203933
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.202946
MED12 mediator complex subunit 12 0.202618
GC group-specific component (vitamin D binding protein) 0.200331
FNDC1 fibronectin type III domain containing 1 0.199681
CD69 CD69 molecule 0.198386
CBS cystathionine-beta-synthase 0.19742
PTER phosphotriesterase related 0.196139
OTX2 orthodenticle homeobox 2 0.194865
CNR1 cannabinoid receptor 1 (brain) 0.194548
WNT2 wingless-type MMTV integration site family member 2 0.192657
GHRH growth hormone releasing hormone 0.192344
LPAR4 lysophosphatidic acid receptor 4 0.192031
CTSA cathepsin A 0.192031
SMAD4 SMAD family member 4 0.192031
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.192031
GGT1 gamma-glutamyltransferase 1 0.191408
PLAU plasminogen activator, urokinase 0.190476
NPAT nuclear protein, ataxia-telangiectasia locus 0.190476
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.189859
SLC26A8 solute carrier family 26 (anion exchanger), member 8 0.189551
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 0.189244
MAK male germ cell-associated kinase 0.188632
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.188022
LRRC6 leucine rich repeat containing 6 0.187113
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 0.18651
ERRFI1 ERBB receptor feedback inhibitor 1 0.18621
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.185016
ZAR1 zygote arrest 1 0.184128
MLH1 mutL homolog 1 0.184128
CCDC39 coiled-coil domain containing 39 0.183835
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 0.183248
SERBP1 SERPINE1 mRNA binding protein 1 0.182375
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 0.18151
FADS2 fatty acid desaturase 2 0.180937
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.180367
GPR84 G protein-coupled receptor 84 0.180084
ISM1 isthmin 1, angiogenesis inhibitor 0.179802
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 0.17896
CREB1 cAMP responsive element binding protein 1 0.178126
DCP1A decapping mRNA 1A 0.177851
TPH2 tryptophan hydroxylase 2 0.177851
CPEB1 cytoplasmic polyadenylation element binding protein 1 0.177301
MLH3 mutL homolog 3 0.176485
NMRK2 nicotinamide riboside kinase 2 0.175146
GUCA2B guanylate cyclase activator 2B (uroguanylin) 0.174617
THRA thyroid hormone receptor, alpha 0.174354
LY96 lymphocyte antigen 96 0.174093
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.173832
LPAR5 lysophosphatidic acid receptor 5 0.171286
UNG uracil-DNA glycosylase 0.171036
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.170789
TDRD1 tudor domain containing 1 0.170299
JUN jun proto-oncogene 0.170054
RBMXL1 RNA binding motif protein, X-linked-like 1 0.169091
LEFTY2 left-right determination factor 2 0.168617
EIF4A1 eukaryotic translation initiation factor 4A1 0.167452
SMAD2 SMAD family member 2 0.167452
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.167224
ZYX zyxin 0.166995
C2CD4B C2 calcium-dependent domain containing 4B 0.166995
TIMP1 TIMP metallopeptidase inhibitor 1 0.166319
CYCS cytochrome c, somatic 0.166319
NGF nerve growth factor (beta polypeptide) 0.166095
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.166095
HIPK1 homeodomain interacting protein kinase 1 0.166095
FLT1 fms-related tyrosine kinase 1 0.165217
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 0.165217
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.165217
AANAT aralkylamine N-acetyltransferase 0.165217
WNT3 wingless-type MMTV integration site family, member 3 0.163111
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.162908
OXTR oxytocin receptor 0.162109
RPL15 ribosomal protein L15 0.161716
GAS1 growth arrest-specific 1 0.161523
NIN ninein (GSK3B interacting protein) 0.160761
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.160387
APOH apolipoprotein H (beta-2-glycoprotein I) 0.160387
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.160203
ADGRG2 adhesion G protein-coupled receptor G2 0.159658
PLA2G1B phospholipase A2, group IB (pancreas) 0.158778
AKR1C3 aldo-keto reductase family 1, member C3 0.158778
STX5 syntaxin 5 0.158434
GJB5 gap junction protein, beta 5, 31.1kDa 0.157602