infertility Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility. (Experimental Factor Ontology, EFO_0000545)
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Genes

256 genes co-occuring with the biological term infertility in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACTL7A actin-like 7A
AHR aryl hydrocarbon receptor
AHRR aryl-hydrocarbon receptor repressor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15 arachidonate 15-lipoxygenase
AMH anti-Mullerian hormone
AMHR2 anti-Mullerian hormone receptor, type II
APOA1 apolipoprotein A-I
APOB apolipoprotein B
APOE apolipoprotein E
AR androgen receptor
AURKC aurora kinase C
AVEN apoptosis, caspase activation inhibitor
AZF1 azoospermia factor 1
BDNF brain-derived neurotrophic factor
BIRC5 baculoviral IAP repeat containing 5
BMP15 bone morphogenetic protein 15
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRDT bromodomain, testis-specific
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3 complement component 3
C5 complement component 5
C9 complement component 9
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALCRL calcitonin receptor-like
CATSPER1 cation channel, sperm associated 1
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDY1 chromodomain protein, Y-linked, 1
CFI complement factor I
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CGA glycoprotein hormones, alpha polypeptide
CGB chorionic gonadotropin, beta polypeptide
CLOCK clock circadian regulator
COMT catechol-O-methyltransferase
CREM cAMP responsive element modulator
CRISP2 cysteine-rich secretory protein 2
CST3 cystatin C
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
DAZ1 deleted in azoospermia 1
DAZ2 deleted in azoospermia 2
DAZ4 deleted in azoospermia 4
DAZL deleted in azoospermia-like
DCXR dicarbonyl/L-xylulose reductase
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25
DICER1 dicer 1, ribonuclease type III
DKKL1 dickkopf-like 1
DMRT1 doublesex and mab-3 related transcription factor 1
DNAH1 dynein, axonemal, heavy chain 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
DROSHA drosha, ribonuclease type III
EGR4 early growth response 4
EIF5A2 eukaryotic translation initiation factor 5A2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
EPPIN epididymal peptidase inhibitor
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETV5 ets variant 5
F5 coagulation factor V (proaccelerin, labile factor)
FAS Fas cell surface death receptor
FATE1 fetal and adult testis expressed 1
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCRL3 Fc receptor-like 3
FGF8 fibroblast growth factor 8 (androgen-induced)
FKBP6 FK506 binding protein 6, 36kDa
FMN2 formin 2
FMR1 fragile X mental retardation 1
FOXL2 forkhead box L2
FOXP3 forkhead box P3
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
GAMT guanidinoacetate N-methyltransferase
GANAB glucosidase, alpha; neutral AB
GDF9 growth differentiation factor 9
GGN gametogenetin
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GREM1 gremlin 1, DAN family BMP antagonist
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GTF2A1L general transcription factor IIA, 1-like
H19 H19, imprinted maternally expressed transcript (non-protein coding)
H2BFWT H2B histone family, member W, testis-specific
HABP2 hyaluronan binding protein 2
HFE hemochromatosis
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGB1 high mobility group box 1
HOXA10 homeobox A10
HOXA11 homeobox A11
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA2 heat shock 70kDa protein 2
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IL10 interleukin 10
IL11 interleukin 11
IL17A interleukin 17A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
ING2 inhibitor of growth family, member 2
INS insulin
INSL3 insulin-like 3 (Leydig cell)
ITGA1 integrin, alpha 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KIAA0101 KIAA0101
KIF2C kinesin family member 2C
LEP leptin
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LIF leukemia inhibitory factor
LIG4 ligase IV, DNA, ATP-dependent
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LOXL4 lysyl oxidase-like 4
MBL2 mannose-binding lectin (protein C) 2, soluble
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MICA MHC class I polypeptide-related sequence A
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MLH3 mutL homolog 3
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MOV10L1 Mov10 RISC complex RNA helicase like 1
MSH5 mutS homolog 5
MSMB microseminoprotein, beta-
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
MUC1 mucin 1, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC4 mucin 4, cell surface associated
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCAM1 neural cell adhesion molecule 1
NCR1 natural cytotoxicity triggering receptor 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP3 NLR family, pyrin domain containing 3
NLRP5 NLR family, pyrin domain containing 5
NOS3 nitric oxide synthase 3 (endothelial cell)
NXF2 nuclear RNA export factor 2
OAZ3 ornithine decarboxylase antizyme 3
OGG1 8-oxoguanine DNA glycosylase
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OXT oxytocin/neurophysin I prepropeptide
OXTR oxytocin receptor
PACRG PARK2 co-regulated
PAEP progestagen-associated endometrial protein
PCSK5 proprotein convertase subtilisin/kexin type 5
PDIA3 protein disulfide isomerase family A, member 3
PEPD peptidase D
PGR progesterone receptor
PIWIL1 piwi-like RNA-mediated gene silencing 1
PIWIL2 piwi-like RNA-mediated gene silencing 2
PLAU plasminogen activator, urokinase
PLCZ1 phospholipase C, zeta 1
POLG polymerase (DNA directed), gamma
PON1 paraoxonase 1
PON2 paraoxonase 2
PRDM9 PR domain containing 9
PRL prolactin
PRM1 protamine 1
PRM2 protamine 2
PRM3 protamine 3
PRSS21 protease, serine, 21 (testisin)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PUM2 pumilio RNA-binding family member 2
PYGO2 pygopus family PHD finger 2
RABL2A RAB, member of RAS oncogene family-like 2A
RAG1 recombination activating gene 1
REC8 REC8 meiotic recombination protein
SCARB1 scavenger receptor class B, member 1
SEMG1 semenogelin I
SEMG2 semenogelin II
SEPT12 septin 12
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHBG sex hormone-binding globulin
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC26A8 solute carrier family 26 (anion exchanger), member 8
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNRPN small nuclear ribonucleoprotein polypeptide N
SOD2 superoxide dismutase 2, mitochondrial
SOX11 SRY (sex determining region Y)-box 11
SPAG16 sperm associated antigen 16
SPATA16 spermatogenesis associated 16
SPATA9 spermatogenesis associated 9
SPO11 SPO11 meiotic protein covalently bound to DSB
SPP1 secreted phosphoprotein 1
SRY sex determining region Y
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TBC1D20 TBC1 domain family, member 20
TFF3 trefoil factor 3 (intestinal)
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TIMP1 TIMP metallopeptidase inhibitor 1
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNP1 transition protein 1 (during histone to protamine replacement)
TNP2 transition protein 2 (during histone to protamine replacement)
TP53 tumor protein p53
TRO trophinin
TSPY1 testis specific protein, Y-linked 1
TSPYL1 TSPY-like 1
TSSK2 testis-specific serine kinase 2
TSSK4 testis-specific serine kinase 4
TSSK6 testis-specific serine kinase 6
TXNDC2 thioredoxin domain containing 2 (spermatozoa)
TYK2 tyrosine kinase 2
UBE2B ubiquitin-conjugating enzyme E2B
USP26 ubiquitin specific peptidase 26
USP9Y ubiquitin specific peptidase 9, Y-linked
VDAC2 voltage-dependent anion channel 2
VEGFA vascular endothelial growth factor A
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
YBX2 Y box binding protein 2
ZP1 zona pellucida glycoprotein 1 (sperm receptor)
ZP2 zona pellucida glycoprotein 2 (sperm receptor)
ZP3 zona pellucida glycoprotein 3 (sperm receptor)