initiates Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

223 genes co-occuring with the biological term initiates in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADGRE5 adhesion G protein-coupled receptor E5
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIRE autoimmune regulator
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APAF1 apoptotic peptidase activating factor 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APP amyloid beta (A4) precursor protein
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ASCL2 achaete-scute family bHLH transcription factor 2
ASTL astacin-like metallo-endopeptidase (M12 family)
ATF4 activating transcription factor 4
ATM ATM serine/threonine kinase
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATXN3 ataxin 3
BACE1 beta-site APP-cleaving enzyme 1
BATF2 basic leucine zipper transcription factor, ATF-like 2
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2L1 BCL2-like 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
C9ORF72 chromosome 9 open reading frame 72
CAMP cathelicidin antimicrobial peptide
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCNB1 cyclin B1
CCND1 cyclin D1
CD247 CD247 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD47 CD47 molecule
CD69 CD69 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP164 centrosomal protein 164kDa
CFL1 cofilin 1 (non-muscle)
CFLAR CASP8 and FADD-like apoptosis regulator
CFP complement factor properdin
CHEK2 checkpoint kinase 2
CIDEA cell death-inducing DFFA-like effector a
CLEC4E C-type lectin domain family 4, member E
CMA1 chymase 1, mast cell
CMKLR1 chemerin chemokine-like receptor 1
COL1A1 collagen, type I, alpha 1
CREB1 cAMP responsive element binding protein 1
CTPS1 CTP synthase 1
CTSB cathepsin B
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DIABLO diablo, IAP-binding mitochondrial protein
DMC1 DNA meiotic recombinase 1
DNASE1 deoxyribonuclease I
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
E2F1 E2F transcription factor 1
EGFR epidermal growth factor receptor
EIF4E eukaryotic translation initiation factor 4E
ERBB2 erb-b2 receptor tyrosine kinase 2
ERI1 exoribonuclease 1
ERP29 endoplasmic reticulum protein 29
ESR2 estrogen receptor 2 (ER beta)
F12 coagulation factor XII (Hageman factor)
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FADD Fas (TNFRSF6)-associated via death domain
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FEN1 flap structure-specific endonuclease 1
FGF23 fibroblast growth factor 23
FGFR1 fibroblast growth factor receptor 1
FGG fibrinogen gamma chain
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FOXO4 forkhead box O4
FOXP1 forkhead box P1
FPR2 formyl peptide receptor 2
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8
GGCX gamma-glutamyl carboxylase
GLI3 GLI family zinc finger 3
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GTF2B general transcription factor IIB
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H2AFX H2A histone family, member X
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST2H2AC histone cluster 2, H2ac
HMGB1 high mobility group box 1
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HTRA2 HtrA serine peptidase 2
HULC hepatocellular carcinoma up-regulated long non-coding RNA
IAPP islet amyloid polypeptide
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IL10 interleukin 10
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INSIG1 insulin induced gene 1
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK1 Janus kinase 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDR kinase insert domain receptor
KNG1 kininogen 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
LCK LCK proto-oncogene, Src family tyrosine kinase
LEP leptin
LGALS3 lectin, galactoside-binding, soluble, 3
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LONP2 lon peptidase 2, peroxisomal
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae)
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAPK8 mitogen-activated protein kinase 8
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR208B microRNA 208b
MIR29A microRNA 29a
MIR499A microRNA 499a
MKL1 megakaryoblastic leukemia (translocation) 1
MST1R macrophage stimulating 1 receptor
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
NCF1C neutrophil cytosolic factor 1C pseudogene
NCF2 neutrophil cytosolic factor 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRC4 NLR family, CARD domain containing 4
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
OSMR oncostatin M receptor
OXTR oxytocin receptor
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PABPN1 poly(A) binding protein, nuclear 1
PAEP progestagen-associated endometrial protein
PARK2 parkin RBR E3 ubiquitin protein ligase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PINK1 PTEN induced putative kinase 1
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
POU5F1 POU class 5 homeobox 1
PRDM16 PR domain containing 16
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRL prolactin
PRLR prolactin receptor
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11B RAB11B, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RB1 retinoblastoma 1
RHOT1 ras homolog family member T1
RHOT2 ras homolog family member T2
ROR1 receptor tyrosine kinase-like orphan receptor 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
SAA1 serum amyloid A1
SELL selectin L
SELPLG selectin P ligand
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAI1 snail family zinc finger 1
SOD1 superoxide dismutase 1, soluble
SOD2 superoxide dismutase 2, mitochondrial
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B
TARDBP TAR DNA binding protein
TCF3 transcription factor 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEAD4 TEA domain family member 4
TECPR1 tectonin beta-propeller repeat containing 1
TGFB1 transforming growth factor, beta 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TM4SF1 transmembrane 4 L six family member 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNF tumor necrosis factor
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TP53 tumor protein p53
TRAP1 TNF receptor-associated protein 1
TSLP thymic stromal lymphopoietin
VEGFA vascular endothelial growth factor A
VIM vimentin
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZEB1 zinc finger E-box binding homeobox 1