initiating Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

209 genes co-occuring with the biological term initiating in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AGER advanced glycosylation end product-specific receptor
AICDA activation-induced cytidine deaminase
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALOX15 arachidonate 15-lipoxygenase
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANKK1 ankyrin repeat and kinase domain containing 1
ANXA1 annexin A1
AQP2 aquaporin 2 (collecting duct)
AR androgen receptor
ATM ATM serine/threonine kinase
AXIN2 axin 2
BACE1 beta-site APP-cleaving enzyme 1
BAX BCL2-associated X protein
BCR breakpoint cluster region
BMP2 bone morphogenetic protein 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD2 bromodomain containing 2
BRD7 bromodomain containing 7
C5 complement component 5
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAMP cathelicidin antimicrobial peptide
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL7 chemokine (C-C motif) ligand 7
CCND3 cyclin D3
CCNH cyclin H
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD300LB CD300 molecule-like family member b
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD5 CD5 molecule
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
COL1A1 collagen, type I, alpha 1
CSPG4 chondroitin sulfate proteoglycan 4
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMBT1 deleted in malignant brain tumors 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DRD2 dopamine receptor D2
ENSA endosulfine alpha
EPCAM epithelial cell adhesion molecule
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC4 excision repair cross-complementation group 4
ERCC6 excision repair cross-complementation group 6
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETV5 ets variant 5
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAS Fas cell surface death receptor
FBLN5 fibulin 5
FBXO10 F-box protein 10
FCAR Fc fragment of IgA receptor
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FGL2 fibrinogen-like 2
FLT1 fms-related tyrosine kinase 1
FURIN furin (paired basic amino acid cleaving enzyme)
GATA1 GATA binding protein 1 (globin transcription factor 1)
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GC group-specific component (vitamin D binding protein)
GJA1 gap junction protein, alpha 1, 43kDa
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRIA1 glutamate receptor, ionotropic, AMPA 1
GSN gelsolin
HDAC1 histone deacetylase 1
HEXA hexosaminidase A (alpha polypeptide)
HLA-B major histocompatibility complex, class I, B
HMGB1 high mobility group box 1
HRAS Harvey rat sarcoma viral oncogene homolog
IDO1 indoleamine 2,3-dioxygenase 1
IFNB1 interferon, beta 1, fibroblast
IL10 interleukin 10
IL11 interleukin 11
IL16 interleukin 16
IL18 interleukin 18
IL33 interleukin 33
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAK2 Janus kinase 2
KARS lysyl-tRNA synthetase
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KLF17 Kruppel-like factor 17
KLK1 kallikrein 1
KMT2A lysine (K)-specific methyltransferase 2A
KRAS Kirsten rat sarcoma viral oncogene homolog
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPA lipoprotein, Lp(a)
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MCM7 minichromosome maintenance complex component 7
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MIR320A microRNA 320a
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MNAT1 MNAT CDK-activating kinase assembly factor 1
MOS v-mos Moloney murine sarcoma viral oncogene homolog
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
NANOG Nanog homeobox
NEUROD1 neuronal differentiation 1
NFE2L2 nuclear factor, erythroid 2-like 2
NOTCH1 notch 1
ORAI1 ORAI calcium release-activated calcium modulator 1
OSBPL9 oxysterol binding protein-like 9
PCDH11X protocadherin 11 X-linked
PCDH11Y protocadherin 11 Y-linked
PDCD1 programmed cell death 1
PER3 period circadian clock 3
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLAU plasminogen activator, urokinase
POU1F1 POU class 1 homeobox 1
POU5F1 POU class 5 homeobox 1
PRKCA protein kinase C, alpha
PRNP prion protein
PROM1 prominin 1
PRPF3 pre-mRNA processing factor 3
PRTN3 proteinase 3
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PTCH1 patched 1
PTEN phosphatase and tensin homolog
RAB4A RAB4A, member RAS oncogene family
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAG1 recombination activating gene 1
RAP1B RAP1B, member of RAS oncogene family
RARA retinoic acid receptor, alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RHEB Ras homolog enriched in brain
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RUNX1 runt-related transcription factor 1
S100A12 S100 calcium binding protein A12
SASS6 spindle assembly 6 homolog (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS3 suppressor of cytokine signaling 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TEK TEK tyrosine kinase, endothelial
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TMPRSS2 transmembrane protease, serine 2
TNF tumor necrosis factor
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPS1 trichorhinophalangeal syndrome I
TSHR thyroid stimulating hormone receptor
TSLP thymic stromal lymphopoietin
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
VDAC1 voltage-dependent anion channel 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WIF1 WNT inhibitory factor 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
WNT1 wingless-type MMTV integration site family, member 1
XDH xanthine dehydrogenase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta