insulin receptor substrate binding Gene Set

Dataset GO Molecular Function Annotations
Category structural or functional annotations
Type molecular function
Description Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. (Gene Ontology, GO_0043560)
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11 genes performing the insulin receptor substrate binding molecular function from the curated GO Molecular Function Annotations dataset.

Symbol Name
GRB2 growth factor receptor-bound protein 2
IGF1R insulin-like growth factor 1 receptor
INSR insulin receptor
INSRR insulin receptor-related receptor
JAK2 Janus kinase 2
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PTPN11 protein tyrosine phosphatase, non-receptor type 11