insulin resistance Gene Set

Dataset HPO Gene-Disease Associations
Category disease or phenotype associations
Type phenotype
Description Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels. (Human Phenotype Ontology, HP_0000855)
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26 genes associated with the insulin resistance phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALMS1 Alstrom syndrome protein 1
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CAV1 caveolin 1, caveolae protein, 22kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
GCK glucokinase (hexokinase 4)
HMGA1 high mobility group AT-hook 1
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
INSR insulin receptor
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
LIPE lipase, hormone-sensitive
LMNA lamin A/C
LMNB2 lamin B2
PAX4 paired box 4
PDX1 pancreatic and duodenal homeobox 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPARG peroxisome proliferator-activated receptor gamma
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PTRF polymerase I and transcript release factor
ZFP57 ZFP57 zinc finger protein
ZMPSTE24 zinc metallopeptidase STE24