insulinoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.|A usually benign, well circumscribed neoplasm arising from the beta cells of the pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin. (Experimental Factor Ontology, EFO_0000549)
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Genes

223 genes co-occuring with the disease insulinoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
INS insulin 2.53746
MEN1 multiple endocrine neoplasia I 2.04281
SST somatostatin 1.9652
GCG glucagon 1.84181
IAPP islet amyloid polypeptide 1.64666
NIT1 nitrilase 1 1.48472
PTPRN protein tyrosine phosphatase, receptor type, N 1.38123
RPS15 ribosomal protein S15 1.37861
FOXM1 forkhead box M1 1.35071
GLP1R glucagon-like peptide 1 receptor 1.33763
PPY pancreatic polypeptide 1.26909
GAST gastrin 1.26821
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.20959
GCK glucokinase (hexokinase 4) 1.20353
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.19704
CHGA chromogranin A 1.18712
CPE carboxypeptidase E 1.16606
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.06984
INSR insulin receptor 1.06522
PDX1 pancreatic and duodenal homeobox 1 1.04504
FFAR1 free fatty acid receptor 1 0.964148
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.93497
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.926692
MRPS31 mitochondrial ribosomal protein S31 0.926279
GIP gastric inhibitory polypeptide 0.915139
SCGN secretagogin, EF-hand calcium binding protein 0.906498
CBLN3 cerebellin 3 precursor 0.889258
G6PC2 glucose-6-phosphatase, catalytic, 2 0.851583
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.841753
CALCA calcitonin-related polypeptide alpha 0.822897
HMX1 H6 family homeobox 1 0.80977
SSTR1 somatostatin receptor 1 0.807308
GJA4 gap junction protein, alpha 4, 37kDa 0.783526
VIP vasoactive intestinal peptide 0.779432
IL1B interleukin 1, beta 0.777795
SYT4 synaptotagmin IV 0.769618
SLC30A10 solute carrier family 30, member 10 0.76431
PCIF1 PDX1 C-terminal inhibiting factor 1 0.757378
SSTR5 somatostatin receptor 5 0.756156
SLC30A8 solute carrier family 30 (zinc transporter), member 8 0.750457
ICA1 islet cell autoantigen 1, 69kDa 0.716828
SSTR2 somatostatin receptor 2 0.715215
REM2 RAS (RAD and GEM)-like GTP binding 2 0.711183
PAX4 paired box 4 0.707157
MACROD1 MACRO domain containing 1 0.698715
ZGLP1 zinc finger, GATA-like protein 1 0.691896
SYN1 synapsin I 0.688692
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.682693
CBLN4 cerebellin 4 precursor 0.682693
RNF175 ring finger protein 175 0.6791
FIGNL1 fidgetin-like 1 0.669936
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) 0.662784
CALCB calcitonin-related polypeptide beta 0.652089
VGF VGF nerve growth factor inducible 0.648928
SYT7 synaptotagmin VII 0.642221
IGF2 insulin-like growth factor 2 0.642221
RPS21 ribosomal protein S21 0.637889
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.636315
SNED1 sushi, nidogen and EGF-like domains 1 0.634742
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 0.628065
INSM1 insulinoma-associated 1 0.624927
RAB3A RAB3A, member RAS oncogene family 0.614747
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.61162
IRS2 insulin receptor substrate 2 0.60303
SYT3 synaptotagmin III 0.596012
TMEM27 transmembrane protein 27 0.595233
NSF N-ethylmaleimide-sensitive factor 0.592895
IGF1 insulin-like growth factor 1 (somatomedin C) 0.583941
SSTR4 somatostatin receptor 4 0.577716
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.576939
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.567609
CPA6 carboxypeptidase A6 0.560616
HADH hydroxyacyl-CoA dehydrogenase 0.558674
NPY neuropeptide Y 0.55712
DDIT3 DNA-damage-inducible transcript 3 0.554403
FOXO1 forkhead box O1 0.553239
TXLNG taxilin gamma 0.548583
NEUROD1 neuronal differentiation 1 0.548195
NACA3P NACA family member 3 pseudogene 0.547807
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.536957
POMC proopiomelanocortin 0.53657
CHGB chromogranin B 0.533475
FURIN furin (paired basic amino acid cleaving enzyme) 0.531154
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.526518
HNF1A HNF1 homeobox A 0.526518
SSTR3 somatostatin receptor 3 0.517649
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.516494
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.514186
CSH2 chorionic somatomammotropin hormone 2 0.505739
STC1 stanniocalcin 1 0.505356
VSX1 visual system homeobox 1 0.498467
GLUD1 glutamate dehydrogenase 1 0.497321
PKLR pyruvate kinase, liver and RBC 0.493885
PTPN21 protein tyrosine phosphatase, non-receptor type 21 0.488549
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.487407
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) 0.480945
SOX6 SRY (sex determining region Y)-box 6 0.479047
SV2C synaptic vesicle glycoprotein 2C 0.478668
HMGN2 high mobility group nucleosomal binding domain 2 0.478289
ERN1 endoplasmic reticulum to nucleus signaling 1 0.475255
PGPEP1 pyroglutamyl-peptidase I 0.474119
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.469576
SNAP23 synaptosomal-associated protein, 23kDa 0.469197
DLL1 delta-like 1 (Drosophila) 0.463149
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.455224
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.45447
SHB Src homology 2 domain containing adaptor protein B 0.445429
GAL galanin/GMAP prepropeptide 0.440162
CCNB2 cyclin B2 0.437906
GJD2 gap junction protein, delta 2, 36kDa 0.435275
PCSK1 proprotein convertase subtilisin/kexin type 1 0.431144
PKM pyruvate kinase, muscle 0.42814
CBLN1 cerebellin 1 precursor 0.419517
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.419142
SV2B synaptic vesicle glycoprotein 2B 0.41727
TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.415024
BTC betacellulin 0.409414
ENO2 enolase 2 (gamma, neuronal) 0.398216
SYT1 synaptotagmin I 0.398216
SNX19 sorting nexin 19 0.395235
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.381481
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.36741
NPS neuropeptide S 0.364824
ISL1 ISL LIM homeobox 1 0.364085
STYX serine/threonine/tyrosine interacting protein 0.357077
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.348981
CPB1 carboxypeptidase B1 (tissue) 0.345308
CASR calcium-sensing receptor 0.344207
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.343473
SCG5 secretogranin V 0.343106
PTH parathyroid hormone 0.342372
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.340173
PC pyruvate carboxylase 0.33944
POU2F2 POU class 2 homeobox 2 0.337242
GHRH growth hormone releasing hormone 0.33651
PRDM2 PR domain containing 2, with ZNF domain 0.336144
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 0.334315
HK1 hexokinase 1 0.333949
NKX2-2 NK2 homeobox 2 0.3292
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.328105
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.327375
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.321909
IRF1 interferon regulatory factor 1 0.321545
NPTX1 neuronal pentraxin I 0.321181
ADM adrenomedullin 0.319726
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.317545
LRRC25 leucine rich repeat containing 25 0.313552
DNAH8 dynein, axonemal, heavy chain 8 0.311739
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.303781
FAM3B family with sequence similarity 3, member B 0.301254
CALB1 calbindin 1, 28kDa 0.298371
SCG3 secretogranin III 0.296931
JUN jun proto-oncogene 0.295851
LUZP4 leucine zipper protein 4 0.293694
MAPK8 mitogen-activated protein kinase 8 0.291539
NPY2R neuropeptide Y receptor Y2 0.286519
SOCS6 suppressor of cytokine signaling 6 0.285086
SV2A synaptic vesicle glycoprotein 2A 0.28294
NCK1 NCK adaptor protein 1 0.280796
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.280439
ELOVL5 ELOVL fatty acid elongase 5 0.280439
NKX6-1 NK6 homeobox 1 0.275445
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.274376
SNAPIN SNAP-associated protein 0.272597
MADD MAP-kinase activating death domain 0.271886
GRP gastrin-releasing peptide 0.269398
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 0.267267
LHX2 LIM homeobox 2 0.266913
CEL carboxyl ester lipase 0.26514
ATF4 activating transcription factor 4 0.264431
ADCY2 adenylate cyclase 2 (brain) 0.260184
GJA1 gap junction protein, alpha 1, 43kDa 0.259124
RAB2A RAB2A, member RAS oncogene family 0.254183
UBE2I ubiquitin-conjugating enzyme E2I 0.250311
CD164 CD164 molecule, sialomucin 0.244696
ZNF79 zinc finger protein 79 0.244345
MNX1 motor neuron and pancreas homeobox 1 0.241895
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.238403
CSN2 casein beta 0.238054
SYP synaptophysin 0.238054
NLRP2 NLR family, pyrin domain containing 2 0.236312
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) 0.230409
CCK cholecystokinin 0.225917
STX1A syntaxin 1A (brain) 0.22454
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 0.220766
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.21974
HES6 hes family bHLH transcription factor 6 0.218715
CHN2 chimerin 2 0.215992
RIMS1 regulating synaptic membrane exocytosis 1 0.212945
CASC5 cancer susceptibility candidate 5 0.211261
GCGR glucagon receptor 0.211261
DPP4 dipeptidyl-peptidase 4 0.207578
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.207578
POU2F1 POU class 2 homeobox 1 0.206248
SPOP speckle-type POZ protein 0.202946
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.200006
GAN gigaxonin 0.19582
PTPRD protein tyrosine phosphatase, receptor type, D 0.194232
GK glycerol kinase 0.193915
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.187113
FOXA2 forkhead box A2 0.186811
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.18651
SMS spermine synthase 0.185612
ATXN10 ataxin 10 0.185612
PRL prolactin 0.185016
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.178682
TXNIP thioredoxin interacting protein 0.177301
VAMP8 vesicle-associated membrane protein 8 0.177029
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 0.175947
SYN2 synapsin II 0.175411
PDE8B phosphodiesterase 8B 0.173314
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.170299
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 0.168148
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.167224
GRPR gastrin-releasing peptide receptor 0.166768
LEP leptin 0.165655
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.162707
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.161331
FOS FBJ murine osteosarcoma viral oncogene homolog 0.160948
FFAR4 free fatty acid receptor 4 0.159838
PAX6 paired box 6 0.159124
GLIS3 GLIS family zinc finger 3 0.158951
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 0.158097