intercalated disc Gene Set

Dataset GO Cellular Component Annotations 2015
Category structural or functional annotations
Type cellular component
Description A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. (Gene Ontology, GO_0014704)
External Link http://amigo.geneontology.org/amigo/term/GO:0014704
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Genes

37 proteins localized to the intercalated disc cellular component from the curated GO Cellular Component Annotations 2015 dataset.

Symbol Name
AKAP6 A kinase (PRKA) anchor protein 6
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD23 ankyrin repeat domain 23
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CAV3 caveolin 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
DLG1 discs, large homolog 1 (Drosophila)
DSC2 desmocollin 2
DSG2 desmoglein 2
DSP desmoplakin
FGF13 fibroblast growth factor 13
GJA1 gap junction protein, alpha 1, 43kDa
GJA5 gap junction protein, alpha 5, 40kDa
GJC1 gap junction protein, gamma 1, 45kDa
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUP junction plakoglobin
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
MYH1 myosin, heavy chain 1, skeletal muscle, adult
OBSL1 obscurin-like 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PGM5 phosphoglucomutase 5
PKP2 plakophilin 2
RANGRF RAN guanine nucleotide release factor
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SCN2A sodium channel, voltage gated, type II alpha subunit
SCN4B sodium channel, voltage gated, type IV beta subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
TJP1 tight junction protein 1
VAMP5 vesicle-associated membrane protein 5
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta