intercalated disc Gene Set

Dataset GO Cellular Component Annotations 2023
Category structural or functional annotations
Type biological process
Description A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells. (Gene Ontology, GO_0014704)
External Link http://amigo.geneontology.org/amigo/term/GO:0014704
Similar Terms
Downloads & Tools

Genes

32 proteins localized to the intercalated disc cellular component from the curated GO Cellular Component Annotations 2023 dataset.

Symbol Name
AKAP6 A kinase (PRKA) anchor protein 6
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CTNNA3 catenin (cadherin-associated protein), alpha 3
CXADR coxsackie virus and adenovirus receptor
DES desmin
DLG1 discs, large homolog 1 (Drosophila)
DSC2 desmocollin 2
DSG2 desmoglein 2
DSP desmoplakin
FGF13 fibroblast growth factor 13
FXYD1 FXYD domain containing ion transport regulator 1
GJA1 gap junction protein, alpha 1, 43kDa
GJA5 gap junction protein, alpha 5, 40kDa
GJC1 gap junction protein, gamma 1, 45kDa
JUP junction plakoglobin
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
NRAP nebulin-related anchoring protein
OBSL1 obscurin-like 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PGM5 phosphoglucomutase 5
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKP2 plakophilin 2
RANGRF RAN guanine nucleotide release factor
SCN1B sodium channel, voltage gated, type I beta subunit
SCN4B sodium channel, voltage gated, type IV beta subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
TMEM65 transmembrane protein 65
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta