internalization Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

436 genes co-occuring with the biological term internalization in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAP1 ArfGAP with dual PH domains 1
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADORA3 adenosine A3 receptor
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRBK1 adrenergic, beta, receptor kinase 1
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AJAP1 adherens junctions associated protein 1
AKAP5 A kinase (PRKA) anchor protein 5
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANTXR1 anthrax toxin receptor 1
ANTXR2 anthrax toxin receptor 2
ANXA1 annexin A1
ANXA2 annexin A2
ANXA5 annexin A5
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
APC adenomatous polyposis coli
APLN apelin
APLNR apelin receptor
APLP1 amyloid beta (A4) precursor-like protein 1
APP amyloid beta (A4) precursor protein
AQP4 aquaporin 4
ARF5 ADP-ribosylation factor 5
ARF6 ADP-ribosylation factor 6
ARR3 arrestin 3, retinal (X-arrestin)
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ARRDC3 arrestin domain containing 3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP7A ATPase, Cu++ transporting, alpha polypeptide
B2M beta-2-microglobulin
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
BICD1 bicaudal D homolog 1 (Drosophila)
BMPR1A bone morphogenetic protein receptor, type IA
C5AR1 complement component 5a receptor 1
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CALCRL calcitonin receptor-like
CALY calcyon neuron-specific vesicular protein
CAMP cathelicidin antimicrobial peptide
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD209 CD209 molecule
CD244 CD244 molecule, natural killer cell receptor 2B4
CD33 CD33 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD3D CD3d molecule, delta (CD3-TCR complex)
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD63 CD63 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CD81 CD81 molecule
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK2 cyclin-dependent kinase 2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHMP3 charged multivesicular body protein 3
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
CHRM1 cholinergic receptor, muscarinic 1
CHRM4 cholinergic receptor, muscarinic 4
CLDN1 claudin 1
CLEC4C C-type lectin domain family 4, member C
CLEC4D C-type lectin domain family 4, member D
CLEC4G C-type lectin domain family 4, member G
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COL17A1 collagen, type XVII, alpha 1
COMMD1 copper metabolism (Murr1) domain containing 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CSF1R colony stimulating factor 1 receptor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CTTN cortactin
CXADR coxsackie virus and adenovirus receptor
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CYSLTR1 cysteinyl leukotriene receptor 1
CYTH1 cytohesin 1
CYTH2 cytohesin 2
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAB2IP DAB2 interacting protein
DCN decorin
DEFB103B defensin, beta 103B
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLG2 discs, large homolog 2 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DNM2 dynamin 2
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DSG2 desmoglein 2
DSG3 desmoglein 3
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDNRA endothelin receptor type A
EEA1 early endosome antigen 1
EFNA1 ephrin-A1
EFNB1 ephrin-B1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ENG endoglin
EPCAM epithelial cell adhesion molecule
EPN1 epsin 1
EPOR erythropoietin receptor
EPS15 epidermal growth factor receptor pathway substrate 15
ERBB2 erb-b2 receptor tyrosine kinase 2
EZR ezrin
F11R F11 receptor
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F7 coagulation factor VII (serum prothrombin conversion accelerator)
F8 coagulation factor VIII, procoagulant component
FAS Fas cell surface death receptor
FCAMR Fc receptor, IgA, IgM, high affinity
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FDPS farnesyl diphosphate synthase
FFAR4 free fatty acid receptor 4
FGA fibrinogen alpha chain
FGF10 fibroblast growth factor 10
FGF2 fibroblast growth factor 2 (basic)
FGF7 fibroblast growth factor 7
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FLNA filamin A, alpha
FLOT1 flotillin 1
FLOT2 flotillin 2
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FSHR follicle stimulating hormone receptor
FZD2 frizzled class receptor 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GCGR glucagon receptor
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GIPC1 GIPC PDZ domain containing family, member 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GJA1 gap junction protein, alpha 1, 43kDa
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPR55 G protein-coupled receptor 55
GRB2 growth factor receptor-bound protein 2
GRK1 G protein-coupled receptor kinase 1
GRK4 G protein-coupled receptor kinase 4
GRK5 G protein-coupled receptor kinase 5
GRM1 glutamate receptor, metabotropic 1
GRM4 glutamate receptor, metabotropic 4
HAMP hepcidin antimicrobial peptide
HCAR2 hydroxycarboxylic acid receptor 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-C major histocompatibility complex, class I, C
HRH2 histamine receptor H2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPG2 heparan sulfate proteoglycan 2
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
IL33R interleukin 33 receptor
IL4R interleukin 4 receptor
IL6ST interleukin 6 signal transducer
ILK integrin-linked kinase
INS insulin
INSR insulin receptor
IQGAP1 IQ motif containing GTPase activating protein 1
IQSEC1 IQ motif and Sec7 domain 1
IRF3 interferon regulatory factor 3
ITGA1 integrin, alpha 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITSN1 intersectin 1 (SH3 domain protein)
JAK2 Janus kinase 2
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
L1CAM L1 cell adhesion molecule
LAMC2 laminin, gamma 2
LAT linker for activation of T cells
LCN1 lipocalin 1
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LHCGR luteinizing hormone/choriogonadotropin receptor
LMBR1L limb development membrane protein 1-like
LPAR1 lysophosphatidic acid receptor 1
LRP1 low density lipoprotein receptor-related protein 1
LRP6 low density lipoprotein receptor-related protein 6
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTB4R leukotriene B4 receptor
LY75 lymphocyte antigen 75
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MC5R melanocortin 5 receptor
MET MET proto-oncogene, receptor tyrosine kinase
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIR762 microRNA 762
MLNR motilin receptor
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPL MPL proto-oncogene, thrombopoietin receptor
MRC2 mannose receptor, C type 2
MRGPRX2 MAS-related GPR, member X2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSN moesin
MSR1 macrophage scavenger receptor 1
MTNR1A melatonin receptor 1A
MTNR1B melatonin receptor 1B
MUC1 mucin 1, cell surface associated
MUC17 mucin 17, cell surface associated
MVP major vault protein
MYD88 myeloid differentiation primary response 88
MYH9 myosin, heavy chain 9, non-muscle
MYLIP myosin regulatory light chain interacting protein
MYLK myosin light chain kinase
NCF4 neutrophil cytosolic factor 4, 40kDa
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPC1L1 NPC1-like 1
NPR1 natriuretic peptide receptor 1
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRP1 neuropilin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUCLEOLIN nucleolin multifunctional protein
NUMB numb homolog (Drosophila)
OCLN occludin
OCRL oculocerebrorenal syndrome of Lowe
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OR3A1 olfactory receptor, family 3, subfamily A, member 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
P2RY11 purinergic receptor P2Y, G-protein coupled, 11
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PANX1 pannexin 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PERP PERP, TP53 apoptosis effector
PHB prohibitin
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PICALM phosphatidylinositol binding clathrin assembly protein
PIGR polymeric immunoglobulin receptor
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLD1 phospholipase D1, phosphatidylcholine-specific
PLD2 phospholipase D2
PLVAP plasmalemma vesicle associated protein
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
PRL prolactin
PRLR prolactin receptor
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PTCH1 patched 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTH1R parathyroid hormone 1 receptor
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
PTRF polymerase I and transcript release factor
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RAB5A RAB5A, member RAS oncogene family
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RELN reelin
RGS9 regulator of G-protein signaling 9
RHOA ras homolog family member A
RIN1 Ras and Rab interactor 1
RIT2 Ras-like without CAAX 2
RNASE3 ribonuclease, RNase A family, 3
RNASE7 ribonuclease, RNase A family, 7
RNF115 ring finger protein 115
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPSA ribosomal protein SA
RSPO1 R-spondin 1
S100A10 S100 calcium binding protein A10
S100B S100 calcium binding protein B
S1PR1 sphingosine-1-phosphate receptor 1
SCARB1 scavenger receptor class B, member 1
SCARB2 scavenger receptor class B, member 2
SCNN1D sodium channel, non voltage gated 1 delta subunit
SELE selectin E
SELL selectin L
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SH3BP4 SH3-domain binding protein 4
SHH sonic hedgehog
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SMAD2 SMAD family member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX5 sorting nexin 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SSTR2 somatostatin receptor 2
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAB1 stabilin 1
STIM1 stromal interaction molecule 1
SYK spleen tyrosine kinase
TACR1 tachykinin receptor 1
TBP TATA box binding protein
TBXA2R thromboxane A2 receptor
TEK TEK tyrosine kinase, endothelial
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THOP1 thimet oligopeptidase 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNC tenascin C
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TRHR thyrotropin-releasing hormone receptor
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSHR thyroid stimulating hormone receptor
TXNIP thioredoxin interacting protein
TYK2 tyrosine kinase 2
UBE2D2 ubiquitin-conjugating enzyme E2D 2
VAV2 vav 2 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VIPR1 vasoactive intestinal peptide receptor 1
VNN1 vanin 1
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
VTN vitronectin
WNT3 wingless-type MMTV integration site family, member 3
WNT5A wingless-type MMTV integration site family, member 5A
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF143 zinc finger protein 143