intracellular signaling cassette Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
External Link http://amigo.geneontology.org/amigo/term/GO:0141124
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Genes

355 genes participating in the intracellular signaling cassette biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABR active BCR-related
ACKR2 atypical chemokine receptor 2
ACKR3 atypical chemokine receptor 3
ACKR4 atypical chemokine receptor 4
ADAM17 ADAM metallopeptidase domain 17
ADAM8 ADAM metallopeptidase domain 8
AGTR1 angiotensin II receptor, type 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APP amyloid beta (A4) precursor protein
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP1 Rho GTPase activating protein 1
ARHGAP12 Rho GTPase activating protein 12
ARHGAP15 Rho GTPase activating protein 15
ARHGAP18 Rho GTPase activating protein 18
ARHGAP27 Rho GTPase activating protein 27
ARHGAP30 Rho GTPase activating protein 30
ARHGAP31 Rho GTPase activating protein 31
ARHGAP32 Rho GTPase activating protein 32
ARHGAP33 Rho GTPase activating protein 33
ARHGAP8 Rho GTPase activating protein 8
ARHGAP9 Rho GTPase activating protein 9
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARL3 ADP-ribosylation factor-like 3
ATF4 activating transcription factor 4
ATG14 autophagy related 14
BATF basic leucine zipper transcription factor, ATF-like
BATF2 basic leucine zipper transcription factor, ATF-like 2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCL3 B-cell CLL/lymphoma 3
BCR breakpoint cluster region
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTK Bruton agammaglobulinemia tyrosine kinase
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1QBP complement component 1, q subcomponent binding protein
C3AR1 complement component 3a receptor 1
C6ORF89 chromosome 6 open reading frame 89
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CARD11 caspase recruitment domain family, member 11
CCDC88A coiled-coil domain containing 88A
CCDC88C coiled-coil domain containing 88C
CCL20 chemokine (C-C motif) ligand 20
CCL3 chemokine (C-C motif) ligand 3
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCR8 chemokine (C-C motif) receptor 8
CCR9 chemokine (C-C motif) receptor 9
CCRL2 chemokine (C-C motif) receptor-like 2
CD160 CD160 molecule
CD36 CD36 molecule (thrombospondin receptor)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CGAS cyclic GMP-AMP synthase
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHRM3 cholinergic receptor, muscarinic 3
CHUK conserved helix-loop-helix ubiquitous kinase
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLSTN1 calsyntenin 1
CNOT6 CCR4-NOT transcription complex, subunit 6
CREB1 cAMP responsive element binding protein 1
CREB3L4 cAMP responsive element binding protein 3-like 4
CREBBP CREB binding protein
CREBZF CREB/ATF bZIP transcription factor
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CXCR6 chemokine (C-X-C motif) receptor 6
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT3 DNA-damage-inducible transcript 3
DEFB1 defensin, beta 1
DEFB124 defensin, beta 124
DELE1 DAP3 binding cell death enhancer 1
DGKH diacylglycerol kinase, eta
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DUSP9 dual specificity phosphatase 9
EDN1 endothelin 1
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EGFR epidermal growth factor receptor
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FGF13 fibroblast growth factor 13
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FPR1 formyl peptide receptor 1
FPR2 formyl peptide receptor 2
GAB2 GRB2-associated binding protein 2
GATA3 GATA binding protein 3
GDNF glial cell derived neurotrophic factor
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HIPK2 homeodomain interacting protein kinase 2
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL31RA interleukin 31 receptor A
IRAG1 inositol 1,4,5-triphosphate receptor associated 1
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRS1 insulin receptor substrate 1
JUN jun proto-oncogene
KRIT1 KRIT1, ankyrin repeat containing
KSR2 kinase suppressor of ras 2
LACRT lacritin
LRP2 low density lipoprotein receptor-related protein 2
LRRK2 leucine-rich repeat kinase 2
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP2K3 mitogen-activated protein kinase kinase 3
MAP2K4 mitogen-activated protein kinase kinase 4
MAP2K5 mitogen-activated protein kinase kinase 5
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K19 mitogen-activated protein kinase kinase kinase 19
MAP3K20 mitogen-activated protein kinase kinase kinase 20
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK1 mitogen-activated protein kinase 1
MAPK12 mitogen-activated protein kinase 12
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCTP1 multiple C2 domains, transmembrane 1
MCTP2 multiple C2 domains, transmembrane 2
MCU mitochondrial calcium uniporter
MEF2A myocyte enhancer factor 2A
MEF2C myocyte enhancer factor 2C
MEN1 multiple endocrine neoplasia I
MINDY4 MINDY lysine 48 deubiquitinase 4
MINK1 misshapen-like kinase 1
MKRN2 makorin ring finger protein 2
MOCOS molybdenum cofactor sulfurase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO16 myosin XVI
MYO18A myosin XVIIIA
NANOS1 nanos homolog 1 (Drosophila)
NANOS2 nanos homolog 2 (Drosophila)
NANOS3 nanos homolog 3 (Drosophila)
NCALD neurocalcin delta
NDNF neuron-derived neurotrophic factor
NF1 neurofibromin 1
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFE2L3 nuclear factor, erythroid 2-like 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC3 NLR family, CARD domain containing 3
NMUR1 neuromedin U receptor 1
NPPA natriuretic peptide A
NPPB natriuretic peptide B
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRTN neurturin
NUCB1 nucleobindin 1
NUCB2 nucleobindin 2
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NYAP1 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
OMA1 OMA1 zinc metallopeptidase
OPRL1 opiate receptor-like 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PABPN1 poly(A) binding protein, nuclear 1
PDE10A phosphodiesterase 10A
PDE11A phosphodiesterase 11A
PDE1A phosphodiesterase 1A, calmodulin-dependent
PDE1B phosphodiesterase 1B, calmodulin-dependent
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE3A phosphodiesterase 3A, cGMP-inhibited
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4C phosphodiesterase 4C, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDE5A phosphodiesterase 5A, cGMP-specific
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDE7A phosphodiesterase 7A
PDE7B phosphodiesterase 7B
PDE8A phosphodiesterase 8A
PDE8B phosphodiesterase 8B
PDE9A phosphodiesterase 9A
PDPK1 3-phosphoinositide dependent protein kinase 1
PIAS2 protein inhibitor of activated STAT, 2
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PKN1 protein kinase N1
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLCD1 phospholipase C, delta 1
PLCD4 phospholipase C, delta 4
PLCE1 phospholipase C, epsilon 1
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLVAP plasmalemma vesicle associated protein
POMC proopiomelanocortin
POU4F2 POU class 4 homeobox 2
PPAN-P2RY11 PPAN-P2RY11 readthrough
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PPP5C protein phosphatase 5, catalytic subunit
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCA protein kinase C, alpha
PRKCSH protein kinase C substrate 80K-H
PTEN phosphatase and tensin homolog
PTGDR2 prostaglandin D2 receptor 2
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPN7 protein tyrosine phosphatase, non-receptor type 7
QRICH1 glutamine-rich 1
RAB18 RAB18, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAB6C RAB6C, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RASL10A RAS-like, family 10, member A
RBPMS RNA binding protein with multiple splicing
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCAN1 regulator of calcineurin 1
RCAN2 regulator of calcineurin 2
RCAN3 RCAN family member 3
RCE1 Ras converting CAAX endopeptidase 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
REPS1 RALBP1 associated Eps domain containing 1
RERG RAS-like, estrogen-regulated, growth inhibitor
RGS19 regulator of G-protein signaling 19
RHEB Ras homolog enriched in brain
RHEBL1 Ras homolog enriched in brain like 1
RILPL1 Rab interacting lysosomal protein-like 1
RIN2 Ras and Rab interactor 2
RIPK2 receptor-interacting serine-threonine kinase 2
RIT2 Ras-like without CAAX 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE3 ribonuclease, RNase A family, 3
RNASEH2A ribonuclease H2, subunit A
RRAD Ras-related associated with diabetes
RRAGC Ras-related GTP binding C
RUNDC3A RUN domain containing 3A
RUNX2 runt-related transcription factor 2
RYR2 ryanodine receptor 2 (cardiac)
SAMD14 sterile alpha motif domain containing 14
SBK2 SH3 domain binding kinase family, member 2
SCG2 secretogranin II
SELE selectin E
SHANK3 SH3 and multiple ankyrin repeat domains 3
SIAH2 siah E3 ubiquitin protein ligase 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SMAD9 SMAD family member 9
SPHK1 sphingosine kinase 1
SPNS1 spinster homolog 1 (Drosophila)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TANK TRAF family member-associated NFKB activator
TAOK3 TAO kinase 3
TBK1 TANK-binding kinase 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
TMPRSS4 transmembrane protease, serine 4
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNIK TRAF2 and NCK interacting kinase
TNK2 tyrosine kinase, non-receptor, 2
TPCN2 two pore segment channel 2
TRADD TNFRSF1A-associated via death domain
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREML1 triggering receptor expressed on myeloid cells-like 1
TRIM8 tripartite motif containing 8
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC2 tuberous sclerosis 2
TYRO3 TYRO3 protein tyrosine kinase
USP17L2 ubiquitin specific peptidase 17-like family member 2
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WWTR1 WW domain containing transcription regulator 1
XBP1 X-box binding protein 1
XCR1 chemokine (C motif) receptor 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZDHHC9 zinc finger, DHHC-type containing 9
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZMIZ2 zinc finger, MIZ-type containing 2