intrahepatic cholestasis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Xref MGI. (Human Disease Ontology, DOID_1852)
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Genes

119 genes co-occuring with the disease intrahepatic cholestasis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.94002
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 2.6797
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 2.60914
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.51358
NR1H4 nuclear receptor subfamily 1, group H, member 4 1.85
ALPPL2 alkaline phosphatase, placental-like 2 1.68
ALPP alkaline phosphatase, placental 1.67955
ALPL alkaline phosphatase, liver/bone/kidney 1.67864
GGT1 gamma-glutamyltransferase 1 1.62291
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 1.41665
CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 1.39695
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.22649
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.21955
GGT2 gamma-glutamyltransferase 2 1.21782
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.18669
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.12445
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.12066
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 1.09839
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.08244
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.07656
ASS1 argininosuccinate synthase 1 1.05597
NR0B2 nuclear receptor subfamily 0, group B, member 2 1.01976
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 1.01596
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 0.99233
CDC50B cell division cycle 50 P4-ATPase accessory subunit B 0.991909
SLCO1B1 solute carrier organic anion transporter family, member 1B1 0.952856
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.948269
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 0.911845
MARS methionyl-tRNA synthetase 0.892948
BAAT bile acid CoA:amino acid N-acyltransferase 0.88434
ATP8B4 ATPase, class I, type 8B, member 4 0.842573
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.829459
GPBAR1 G protein-coupled bile acid receptor 1 0.812642
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.804846
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.787213
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.782298
JAG1 jagged 1 0.776159
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase 0.738271
ALB albumin 0.728952
LCAT lecithin-cholesterol acyltransferase 0.701526
DNAH8 dynein, axonemal, heavy chain 8 0.694301
AP1S1 adaptor-related protein complex 1, sigma 1 subunit 0.688692
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 0.681096
SLC51B solute carrier family 51, beta subunit 0.680697
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 0.675909
ERP29 endoplasmic reticulum protein 29 0.671925
ATP11C ATPase, class VI, type 11C 0.662387
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 0.64577
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.640251
CYP8B1 cytochrome P450, family 8, subfamily B, polypeptide 1 0.634742
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 0.632777
AQP8 aquaporin 8 0.614747
LAP3 leucine aminopeptidase 3 0.604201
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.597961
LIN37 lin-37 DREAM MuvB core complex component 0.585887
FGF19 fibroblast growth factor 19 0.575772
KIFC3 kinesin family member C3 0.561392
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.528835
RXRA retinoid X receptor, alpha 0.526132
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 0.511112
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.508041
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 0.496557
CCBE1 collagen and calcium binding EGF domains 1 0.49274
NT5E 5'-nucleotidase, ecto (CD73) 0.487027
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.487027
GCOM1 GRINL1A complex locus 1 0.475255
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.469576
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.456355
MYO5B myosin VB 0.452585
F2 coagulation factor II (thrombin) 0.445429
GPR176 G protein-coupled receptor 176 0.445052
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.43227
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.431519
SLCO1A2 solute carrier organic anion transporter family, member 1A2 0.431519
XYLT2 xylosyltransferase II 0.429642
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.429266
CELA1 chymotrypsin-like elastase family, member 1 0.421016
CELA3B chymotrypsin-like elastase family, member 3B 0.411283
RELT RELT tumor necrosis factor receptor 0.385936
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.380739
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.37592
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 0.367779
TJP1 tight junction protein 1 0.363716
RAB11A RAB11A, member RAS oncogene family 0.359289
FABP6 fatty acid binding protein 6, ileal 0.35892
FOXA2 forkhead box A2 0.356341
AFP alpha-fetoprotein 0.352291
ESR2 estrogen receptor 2 (ER beta) 0.351923
SCO1 SCO1 cytochrome c oxidase assembly protein 0.348246
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.339806
PEX2 peroxisomal biogenesis factor 2 0.324823
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.322637
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.310652
LIPC lipase, hepatic 0.301254
TTC34 tetratricopeptide repeat domain 34 0.294413
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.275801
CCDC27 coiled-coil domain containing 27 0.273664
POR P450 (cytochrome) oxidoreductase 0.268687
PEMT phosphatidylethanolamine N-methyltransferase 0.261599
GABRD gamma-aminobutyric acid (GABA) A receptor, delta 0.25983
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.25207
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 0.248554
DLAT dihydrolipoamide S-acetyltransferase 0.244345
CARM1 coactivator-associated arginine methyltransferase 1 0.231448
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.226262
POLB polymerase (DNA directed), beta 0.225573
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.224196
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C 0.207578
PPARA peroxisome proliferator-activated receptor alpha 0.201635
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.194232
PLD2 phospholipase D2 0.175679
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.16933
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.16933
TJP2 tight junction protein 2 0.162109
HLA-E major histocompatibility complex, class I, E 0.160387
HEXDC hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing 0.15948
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 0.158605
CSH2 chorionic somatomammotropin hormone 2 0.158434
LPA lipoprotein, Lp(a) 0.157929