intrinsic apoptotic signaling pathway by p53 class mediator Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered. (Gene Ontology, GO_0072332)
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47 genes participating in the intrinsic apoptotic signaling pathway by p53 class mediator biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AEN apoptosis enhancing nuclease
BAG6 BCL2-associated athanogene 6
BAX BCL2-associated X protein
BCL3 B-cell CLL/lymphoma 3
BOK BCL2-related ovarian killer
BRCA2 breast cancer 2, early onset
CDIP1 cell death-inducing p53 target 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DDIT4 DNA-damage-inducible transcript 4
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
EDA2R ectodysplasin A2 receptor
EP300 E1A binding protein p300
FHIT fragile histidine triad
HINT1 histidine triad nucleotide binding protein 1
HIPK1 homeodomain interacting protein kinase 1
HIPK2 homeodomain interacting protein kinase 2
IFI16 interferon, gamma-inducible protein 16
JMY junction mediating and regulatory protein, p53 cofactor
MSH2 mutS homolog 2
MYBBP1A MYB binding protein (P160) 1a
NUPR1 nuclear protein, transcriptional regulator, 1
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PERP PERP, TP53 apoptosis effector
PGAP2 post-GPI attachment to proteins 2
PHLDA3 pleckstrin homology-like domain, family A, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PYCARD PYD and CARD domain containing
RPS27L ribosomal protein S27-like
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SHISA5 shisa family member 5
SIRT1 sirtuin 1
SNW1 SNW domain containing 1
STK11 serine/threonine kinase 11
TMEM109 transmembrane protein 109
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TP73 tumor protein p73
USP28 ubiquitin specific peptidase 28
WWOX WW domain containing oxidoreductase
ZNF385B zinc finger protein 385B